Zubkova S T, Epshteĭn E V, Bulat O V, Bezverkhaia T P, Skrobonskaia N A
Sov Med. 1991(12):16-8.
To investigate pathogenesis of arterial hypertension in diabetes mellitus, the authors measured parameters of central and peripheral hemodynamics, basal renin levels, angiotensin, aldosterone, kallikrein-kinin system. The results were analysed with regard to hypertension type: essential (EH), atherosclerotic (AH) and nephrogenic (NH). Hypokinetic circulation, defected vascular elasticity, activation of renin-angiotensin-aldosterone system and hypoactivity of kallikrein-kinin system were characteristic of EH and AH. Most pronounced changes in peripheral hemodynamics and hypoactivity of depressor kallikrein-kinin system were seen in NH.
为研究糖尿病患者动脉高血压的发病机制，作者测量了中心和外周血流动力学参数、基础肾素水平、血管紧张素、醛固酮以及激肽释放酶-激肽系统。针对高血压类型：原发性（EH）、动脉粥样硬化性（AH）和肾性（NH）对结果进行了分析。EH和AH的特征为低动力循环、血管弹性缺陷、肾素-血管紧张素-醛固酮系统激活以及激肽释放酶-激肽系统活性降低。NH患者外周血流动力学变化最为明显，且降压激肽释放酶-激肽系统活性降低。
