Tan C C, Guan R, Yap I, Tay H H, Kang J Y
Department of Medicine, National University Hospital, Singapore.
Trans R Soc Trop Med Hyg. 1991 Sep-Oct;85(5):656-9. doi: 10.1016/0035-9203(91)90384-b.
Hepatitis B serology was performed on 270 family members of 78 hepatitis B carriers and hepatitis B e antigen status determined in those found to be HBsAg positive. The mean age of index patients was 38 years (range 3-74) and that of family members was 28 years (range 1-71). 67 family members (25%) were HBsAg positive. The proportions of family members positive for HBsAg and those negative for HBsAg but positive for anti-HBs and/or anti-HBc were 25% and 20% for children, 10% and 68% for spouses, 36% and 26% for siblings and 29% and 55% for parents. For children of index parents the proportions positive for HBsAg and those negative for HBsAg but positive for anti-HBs and/or anti-HBc were similar whether the index patient was the mother (24% and 24%) or the father (26% and 18%). Our results suggest that horizontal transmission is a significant mode of spread of hepatitis B within the family in Singapore.
对78名乙肝携带者的270名家庭成员进行了乙肝血清学检测，并对那些HBsAg呈阳性者测定了乙肝e抗原状态。索引患者的平均年龄为38岁（范围3 - 74岁），家庭成员的平均年龄为28岁（范围1 - 71岁）。67名家庭成员（25%）HBsAg呈阳性。HBsAg呈阳性的家庭成员以及HBsAg呈阴性但抗-HBs和/或抗-HBc呈阳性的家庭成员比例，儿童分别为25%和20%，配偶分别为10%和68%，兄弟姐妹分别为36%和26%，父母分别为29%和55%。对于索引父母的子女，无论索引患者是母亲（24%和24%）还是父亲（26%和18%），HBsAg呈阳性的比例以及HBsAg呈阴性但抗-HBs和/或抗-HBc呈阳性的比例都相似。我们的结果表明，在新加坡，水平传播是乙肝在家庭内传播的一种重要方式。
