Chakravarty R, Chowdhury A, Chaudhuri S, Santra A, Neogi M, Rajendran K, Panda C K, Chakravarty M
ICMR Virus Unit, ID and BG Hospital Campus, Kolkata, GB-4, 1st Floor, 57 Dr SC Banerjee Road, Kolkata 700010, India.
Public Health. 2005 Jul;119(7):647-54. doi: 10.1016/j.puhe.2004.09.007.
India, with its 43 million hepatitis B virus (HBV) carriers and absence of any national immunization programme, adds a substantial number of HBV infections to the HBV carrier pool yearly. The aim of this study was to assess the spread of HBV infection in families with an infected member and to identify the family members with the highest risk of infection in our community.
A total of 937 serum samples from 215 HBV-infected cases and 722 members of their households were screened prospectively for markers of HBV by commercial enzyme-linked immunosorbent assay.
Among family members, 140 (19.4%) were HBsAg positive and 272 (37.6%) were negative for HBsAg but positive for either anti HBc or anti HBs. There were 145 HBsAg-positive adults among the index cases whose 133 adult siblings, 59 spouses and 59 mothers participated in the study. Interestingly, 28.81% mothers and 28.57% adult siblings of these adult index cases were positive for HBsAg compared with only 8.75% of their spouses (P < 0.001). Only 15.2% of the HBsAg-positive women in the childbearing age group were found to be HBeAg positive.
Our results suggest that intrafamilial childhood horizontal transmission is important for HBV transmission in our community, and highlight the need for screening of adult siblings and mothers of adult HBsAg carriers in addition to their spouses and children.
印度有4300万乙肝病毒（HBV）携带者，且没有任何国家免疫规划，每年新增大量HBV感染病例进入HBV携带者群体。本研究的目的是评估HBV感染在有感染成员的家庭中的传播情况，并确定我们社区中感染风险最高的家庭成员。
通过商业酶联免疫吸附试验，对来自215例HBV感染病例及其722名家庭成员的共937份血清样本进行前瞻性HBV标志物筛查。
在家庭成员中，140人（19.4%）HBsAg阳性，272人（37.6%）HBsAg阴性，但抗-HBc或抗-HBs阳性。在索引病例中有145名HBsAg阳性成年人，其133名成年兄弟姐妹、59名配偶和59名母亲参与了研究。有趣的是，这些成年索引病例的28.81%母亲和28.57%成年兄弟姐妹HBsAg阳性，而其配偶中只有8.75%阳性（P<0.001）。在育龄期HBsAg阳性女性中，仅1
