Sarma P S, Durairaj P
Department of Medicine, Jawaharlal Nehru Hospital and Research Centre, Bhilainagar, Madhya Pradesh, India.
Trans R Soc Trop Med Hyg. 1991 Sep-Oct;85(5):670-1. doi: 10.1016/0035-9203(91)90390-k.
Forty adult patients with Salmonella typhi and S. paratyphi infections were studied in a randomly assigned prospective study to receive norfloxacin (12 drug-sensitive and 8 drug-resistant cases) or chloramphenicol (20 cases). No complication occurred in either group and no side effect was noted in the norfloxacin-treated group. The results suggest that a 7 d course of twice daily norfloxacin promises to be an alternative to a 14 d course of chloramphenicol for treating chloramphenicol-sensitive and multidrug-resistant typhoid and paratyphoid fevers.
