Colwell R R
Science. 1983 Oct 7;222(4619):19-24. doi: 10.1126/science.222.4619.19.
Genetic engineering applied to the production of fish, molluscs, algae, algal products, and crustaceans in natural environments and hatchery systems is still at the rudimentary stage. Cloning systems for producing commercially important chemicals, pharmacologically active compounds, and metamorphosis-stimulating substances present in marine organisms are being sought. Attempts are being made to develop useful drugs from the sea, including antineoplastic, antibiotic, growth-promoting (or -inhibiting), analgesic, and antispasmodic agents. Immediate commercial applications can be expected from engineered systems involving polysaccharide and specialty chemical production, with marine microorganisms as the source of genetic material.
应用于在自然环境和孵化场系统中生产鱼类、软体动物、藻类、藻类产品及甲壳类动物的基因工程仍处于初级阶段。目前正在寻找用于生产海洋生物中具有商业重要性的化学品、药理活性化合物及变态刺激物质的克隆系统。人们正在尝试从海洋中开发有用的药物,包括抗肿瘤药、抗生素、生长促进(或抑制)剂、镇痛药及解痉药。涉及多糖和特殊化学品生产且以海洋微生物作为遗传物质来源的工程系统有望立即实现商业应用。