Pozharisskiĭ K M, Savost'ianov G A
Vopr Onkol. 1976;22(1):59-68.
Tumors of the rat large intestine induced by subcutaneous injection of 1,2-dimethylhydrazine were studied by the method of electron microscopy. Adenocarcinomas retained histiotypical differentiation and at the same time consisted mostly of cells with a low rate of differentiation. Just on the contrary, in mucous and signet-ring cell carcinomas the picture of an advanced cell differentiation was observed in a complete loss of organogeny. The greatest malignancy of neoplasms (signet-ring carcinoma), which cells are characterized by a high degree of cytological differentiation, is a manifestation of independence of tumor progression signs.
采用电子显微镜方法研究了皮下注射1,2 - 二甲基肼诱导的大鼠大肠肿瘤。腺癌保留了组织学典型分化，同时主要由低分化率的细胞组成。恰恰相反，在黏液癌和印戒细胞癌中，观察到细胞高度分化的现象，同时完全丧失了器官发生能力。肿瘤（印戒细胞癌）的最大恶性程度，其细胞具有高度的细胞学分化特征，是肿瘤进展征象独立性的一种表现。
