Stekar J
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Mar 19;85(3):277-86. doi: 10.1007/BF00284086.
A chromophobic pituitary adenoma induced on BD IX-rats has been grafted on animals of the same strain. The transplanted tumour takes in 90-100%; it grows at a slow rate (in 7 months after grafting a weight of 7-20 g is attained). Tumour-bearing animals display gigantism and hypertrophy of adrenals; moreover, in 33% of cases, diabetes is observed. With non-diabetic animals, splenomegaly and marked leukocytosis are observed; immature white and red cells are present in the peripheral blood. Spontaneous regression of the tumour never occurs. After surgical removal, tumour regrowth and the formation of metastases are observed. Diabetes is characterised by pronounced hyperglycaemia, glucosuria, polyphagia and polydipsia. Histochemically, insulin cannot be detected in pancreas. Splenomegaly is never observed in diabetic animals. Transplanted adenoma frequently tends to stop growing. No recurrence is observable after extirpation. Spontaneous regression of the tumour sometimes occurs. Gigantism, hypertrophy of adrenals and diabetes are considered as consequences of growth hormone- and ACTH-secretion of the transplanted adenoma. At present the tumour is running in the 8th passage. It did not change its characteristics over a period of 5 years.
在BD IX大鼠身上诱发的嫌色性垂体腺瘤已移植到同品系动物身上。移植的肿瘤成活率为90 - 100%；生长缓慢（移植后7个月，肿瘤重量达到7 - 20克）。荷瘤动物表现为巨人症和肾上腺肥大；此外，33%的病例出现糖尿病。非糖尿病动物出现脾肿大和明显的白细胞增多；外周血中存在未成熟的白细胞和红细胞。肿瘤从未自发消退。手术切除后，观察到肿瘤复发和转移形成。糖尿病的特征是明显的高血糖、糖尿、多食和多饮。组织化学检查显示，胰腺中检测不到胰岛素。糖尿病动物从未出现脾肿大。移植的腺瘤常常趋于停止生长。切除后未观察到复发。肿瘤有时会自发消退。巨人症、肾上腺肥大和糖尿病被认为是移植腺瘤分泌生长激素和促肾上腺皮质激素的结果。目前该肿瘤已传至第8代。在5年的时间里，其特征没有改变。
