Bol'shakov I N, Kulaev D V, Silant'eva O V, Lopukhin Iu M
Vestn Akad Med Nauk SSSR. 1991(7):36-40.
An antistaphylococcal and an antitetanic immunosorbents on a silica carrier were tested in diffuse staphylococcal pyocyanic peritonitis to protect receptor expression on the general T and B lymphocyte populations and of Fc-receptors to IgM, IgG and IgA. Plasma of animals with peritonitis was shown to exert a powerful suppressive effect on lymphocyte receptors. Perfusion of toxic plasma over the antistaphylococcal immunosorbents resulted in specific adsorption of microbial toxins and completely prevented Fc gamma-, Fc mu- and Fc alpha-receptor expression on cells. Plasma treated with the antitetanic immunosorbent retained suppressive effects. The low protection of receptors may be explained by nonspecific adsorption of texins.
在弥漫性葡萄球菌绿脓杆菌性腹膜炎中测试了硅胶载体上的抗葡萄球菌和抗破伤风免疫吸附剂，以保护一般T和B淋巴细胞群体以及Fc受体对IgM、IgG和IgA的受体表达。腹膜炎动物的血浆对淋巴细胞受体有强大的抑制作用。将有毒血浆灌注到抗葡萄球菌免疫吸附剂上可导致微生物毒素的特异性吸附，并完全阻止细胞上Fcγ、Fcμ和Fcα受体的表达。用抗破伤风免疫吸附剂处理的血浆保留了抑制作用。受体保护作用低可能是由于毒素的非特异性吸附。
