Geddes S M, Thorburn J, Logan R W
Department of Anaesthesia, Queen Mother's Hospital, Yorkhill, Glasgow.
Anaesthesia. 1991 Dec;46(12):1016-8. doi: 10.1111/j.1365-2044.1991.tb09912.x.
The rate of absorption of paracetamol following oral administration was used as an indirect measure of the rate of gastric emptying. This was to determine the effect on gastric motility of the addition of fentanyl to a solution of local anaesthetic given into the epidural space to provide pain relief following Caesarean section. Thirty subjects were randomly allocated to receive either bupivacaine plus fentanyl or bupivacaine alone. The area under the curve of the graph of plasma paracetamol concentration versus time was calculated for each subject at 45 and 90 minutes after administration of the epidural injection, and this value was used as an index of the rate of gastric emptying. This study demonstrated that gastric emptying may be normal immediately following Caesarean section under epidural anaesthesia, but that if fentanyl is added to the epidural solution, gastric emptying is significantly slower in the first 45 minutes following surgery (p less than 0.05).
口服扑热息痛后的吸收速率被用作胃排空速率的间接指标。这是为了确定在剖宫产术后向硬膜外腔注入局部麻醉剂溶液中添加芬太尼对胃动力的影响。30名受试者被随机分配接受布比卡因加芬太尼或仅接受布比卡因。在硬膜外注射给药后45分钟和90分钟，计算每名受试者血浆扑热息痛浓度与时间关系图的曲线下面积，该值用作胃排空速率的指标。本研究表明，剖宫产术后硬膜外麻醉下胃排空可能立即正常，但如果在硬膜外溶液中添加芬太尼，术后前45分钟胃排空明显减慢（p小于0.05）。
