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成年双胞胎血浆游离胆固醇和酯化胆固醇的方差

Variance of plasma free and esterified cholesterol in adult twins.

作者信息

Christian J C, Cheung S W, Kang K, Harmath F P, Huntzinger D J, Powell R C

出版信息

Am J Hum Genet. 1976 Mar;28(2):174-8.

PMID:178179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1684920/
Abstract

Total, free and esterified cholesterol were measured in the plasma, high density lipoproteins, low density lipoproteins, and total cholesterol in the very low density lipoproteins of 141 pairs of adult white male twins. Free cholesterol in plasma, high density lipoproteins and low density lipoproteins had significant genetic variance. Esterified cholesterol had greater total variance in dizygotic than monozygotic twins, interpreted as evidence for greater environmental influences on the two types of twins. After bias due to unequal environmental effects on the two types of twins was removed, there was no significant genetic variance for any esterified fraction of cholesterol.

摘要

对141对成年白人男性双胞胎的血浆、高密度脂蛋白、低密度脂蛋白中的总胆固醇、游离胆固醇和酯化胆固醇，以及极低密度脂蛋白中的总胆固醇进行了测量。血浆、高密度脂蛋白和低密度脂蛋白中的游离胆固醇具有显著的遗传方差。酯化胆固醇在异卵双胞胎中的总方差大于同卵双胞胎，这被解释为环境对这两种双胞胎的影响更大的证据。在消除了由于环境对两种双胞胎的影响不平等所导致的偏差后，胆固醇的任何酯化部分均无显著的遗传方差。

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本文引用的文献

1
A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity.一种估算血清总胆固醇的简化方法及其特异性验证。
J Biol Chem. 1952 Mar;195(1):357-66.
2
SERUM LIPIDS AND SERUM URIC ACID IN HUMAN TWINS.人类双胞胎的血清脂质与血清尿酸
J Lipid Res. 1965 Apr;6:193-205.
3
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.人血清中超离心分离的脂蛋白的分布及化学组成
J Clin Invest. 1955 Sep;34(9):1345-53. doi: 10.1172/JCI103182.
4
The NAS-NRC twin panel: methods of construction of the panel, zygosity diagnosis, and proposed use.美国国家科学院-国家研究理事会双胞胎小组：小组的组建方法、合子性诊断及拟议用途。
Am J Hum Genet. 1967 Mar;19(2):133-61.
5
The National Heart Institute Twin Study.国家心脏研究所双胞胎研究
Acta Genet Med Gemellol (Roma). 1970 Jan-Apr;19(1):243-7. doi: 10.1017/s1120962300025592.
6
Choice of an estimate of genetic variance from twin data.从双胞胎数据中选择遗传方差估计值的方法。
Am J Hum Genet. 1974 Mar;26(2):154-61.
7
Genetic variability of human plasma and erythrocyte lipids.人类血浆和红细胞脂质的遗传变异性。
Lipids. 1971 Aug;6(8):595-600. doi: 10.1007/BF02531142.
8
Letters to the editor: Statistical analysis of genetic variance in twins.致编辑的信：双胞胎遗传方差的统计分析
Am J Hum Genet. 1975 Nov;27(6):807.

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