McGorry P D, Chanen A, McCarthy E, Van Riel R, McKenzie D, Singh B S
National Health and Medical Research Council Schizophrenia Research Unit, Royal Park Hospital, Parkville, Victoria, Australia.
J Nerv Ment Dis. 1991 May;179(5):253-8. doi: 10.1097/00005053-199105000-00002.
Clinical experience with psychotic patients early in the course of their illness suggested that symptoms of posttraumatic stress disorder (PTSD) may not be uncommon after recovery from an acute psychotic episode. Thirty-six patients recovering from an acute psychotic episode within 2 to 3 years of onset of their illness were assessed as inpatients and followed up on two occasions during the year after discharge. The prevalence of PTSD was found to be 46% at 4 months and 35% at 11 months, measured by a questionnaire linked to DSM-III criteria. The relationships between negative symptomatology and PTSD symptoms and between depressive symptomatology and PTSD symptoms were also examined; a significant correlation was found only for the latter. The psychopathological, preventive, and therapeutic implications of these findings are discussed, and future research strategies are proposed.
对精神病患者病程早期的临床经验表明,急性精神病发作康复后,创伤后应激障碍(PTSD)症状可能并不罕见。对36例在发病2至3年内从急性精神病发作中康复的患者作为住院患者进行评估,并在出院后的一年内进行了两次随访。通过与《精神疾病诊断与统计手册》第三版(DSM-III)标准相关的问卷测量,发现创伤后应激障碍的患病率在4个月时为46%,在11个月时为35%。还研究了阴性症状与创伤后应激障碍症状之间以及抑郁症状与创伤后应激障碍症状之间的关系;仅发现后者存在显著相关性。讨论了这些发现的心理病理学、预防和治疗意义,并提出了未来的研究策略。