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[对精神病性体验的反应性创伤后应激障碍:一项系统综述]

[Post-traumatic stress disorder in reaction to psychotic experience: A systematic revue].

作者信息

Galliot G, Very E, Schmitt L, Rouch V, Salles J

机构信息

Service de psychiatrie et psychologie, psychiatrie Toulouse, CHU de Toulouse, 31000 Toulouse, France.

Service de psychiatrie et psychologie, psychiatrie Toulouse, CHU de Toulouse, 31000 Toulouse, France; Inserm UMR 1214, université Paul-Sabatier Toulouse 3, centre hospitalo-universitaire de Toulouse, 31000 Toulouse, France.

出版信息

Encephale. 2019 Dec;45(6):506-512. doi: 10.1016/j.encep.2019.07.006. Epub 2019 Sep 11.

Abstract

BACKGROUND

The update of the Post-Traumatic Stress Disorder (PTSD) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM5) emphasizes the definition of psychological traumatism as an objective and external event. Nevertheless, the scientific debate about the criteriology of PTSD, its clinical pertinence for application and the role of subjective dimension appears still open. Although the relation between psychotrauma and psychosis has been well examined, in the way of trauma as a risk factor for the development of schizophrenia, the potential traumatism represented by the psychotic experience seems to be less known.

OBJECTIVE

This paper aims to provide a state of the art about the PTSD in reaction to psychosis, defined as PTSD post psychosis (PTSD-PP), particularly in epidemiological and psychopathological terms.

METHODS

We performed a bibliographic research on Pubmed using the keywords "post-traumatic stress disorder", "psychological trauma", "schizophrenia review", "psychosis", "first episode psychosis"« », "recovery schizophrenia", with a first screening on titles and abstracts. An acute psychotic episode referred to a decompensation of any pathology of the DSM5-schizophrenia spectrum or other psychotic disorders or to a mood disorder with psychotic features. The articles exclusively interested in the traumatic impact of hospitalizations and treatment conditions were excluded.

RESULTS

The literature noted that PTSD-PP affected about a quarter to a third of the psychotic patients interrogated during the recovery of an acute psychotic episode. The analytic epidemiology showed that the main validated risk factors for PTSD were also relevant in the development of PTSD-PP, including past traumatic history, childhood trauma and feeling of helplessness during the traumatic event. Criticizing the methodological heterogeneity through studies, the observational approach brought out the lack of clinical pertinence of the DSM5A criteria defining the traumatic event for PTSD. This criteriology failed to consider the subjective dimension of the threat to psychological integrity generated by a psychotrauma. Historical case studies presented a complete post-traumatic symptomatology in reaction to psychosis, suggesting that the supposed psychotic residual symptoms after acute phase could referr to actual traumatic reactions. The PTSD-PP process observed in descriptive research and patients' interviews appeared congruent with the cognitive model of PTSD elaborated by Ehlers and Clark. Indeed, psychotic patients developed negative appraisals about themselves, others and the world because of the occurrence and the content of their psychotic symptoms. Shame, fear of recurrence, intolerance to uncertainty and perception of losing control of one's mind were demonstrated as significantly related to PTSD-PP. A perception of current threat then settled, leading to adaptation strategies, possibly psychotic themselves, to avoid intrusions and others indices about their past psychotic episode. Thus, reliving syndrome, avoidance, emotional numbing could simulate a new psychotic exacerbation to an outer-observer.

CONCLUSION

A psychotic experience could be traumatic for patients and lead to complete PTSD. Although it appears as a non-consensual clinical entity, from a likely epistemological slip of the definition of "psychotrauma", the consideration of potential PTSD-PP presents an undoubted clinical relevance. Indeed, it could help practioners to precise the semiological analysis of patients recovering from an acute psychotic episode; to impact the prognosis of psychosis, thinking about impairment on the quality of life and the affective and suicidal comorbidities; and to modify the therapeutic approach in the recovery of schizophrenia. In addition, the literature about psychotic recovery seems particularly related to the concept of "post-traumatic growth" (PTG). The inscription of a psychotic episode in a traumatic frame requires a clinical approach as close as possible to the subjectivity of the patient experience, beyond the evaluation of psychotic symptoms and its remission. The question of trauma-focused therapies applied to PTSD-PP opens the field for future research.

摘要

背景

《精神疾病诊断与统计手册》(DSM5)第五版中创伤后应激障碍(PTSD)的更新强调将心理创伤定义为一个客观的外部事件。然而,关于PTSD的诊断标准、其临床应用相关性以及主观维度的作用的科学辩论似乎仍未结束。尽管心理创伤与精神病之间的关系已得到充分研究,即创伤作为精神分裂症发展的危险因素,但由精神病体验所代表的潜在创伤似乎鲜为人知。

目的

本文旨在提供关于精神病反应性PTSD(定义为精神病后PTSD,PTSD-PP)的最新情况,特别是在流行病学和精神病理学方面。

方法

我们在Pubmed上进行了文献检索,使用关键词“创伤后应激障碍”“心理创伤”“精神分裂症综述”“精神病”“首发精神病”“精神分裂症康复”,首先对标题和摘要进行筛选。急性精神病发作是指DSM5精神分裂症谱系或其他精神病性障碍的任何病理失代偿,或伴有精神病性特征的心境障碍。专门关注住院和治疗条件的创伤性影响的文章被排除。

结果

文献指出,PTSD-PP影响了急性精神病发作康复期间接受询问的约四分之一至三分之一的精神病患者。分析性流行病学表明,PTSD的主要经证实的危险因素在PTSD-PP的发生中也具有相关性,包括过去的创伤史、童年创伤以及创伤事件中的无助感。通过研究批评方法学的异质性,观察性方法揭示了DSM5A中定义PTSD创伤事件的标准缺乏临床相关性。该诊断标准未能考虑心理创伤对心理完整性威胁的主观维度。历史病例研究呈现了对精神病反应的完整创伤后症状,表明急性期后所谓的精神病残留症状可能指的是实际的创伤反应。在描述性研究和患者访谈中观察到的PTSD-PP过程与Ehlers和Clark阐述的PTSD认知模型一致。事实上,精神病患者由于其精神病症状的发生和内容,对自己、他人和世界产生了负面评价。羞耻、对复发的恐惧、对不确定性的不耐受以及对失去思维控制的感知被证明与PTSD-PP显著相关。然后产生了对当前威胁的感知,导致适应策略,这些策略可能本身就是精神病性的,以避免对其过去精神病发作的侵入和其他提示。因此,重温综合征、回避、情感麻木对外界观察者来说可能模拟新的精神病性加重。

结论

精神病体验对患者可能是创伤性的,并导致完全的PTSD。尽管它似乎是一个存在争议的临床实体,可能源于“心理创伤”定义在认识论上的疏忽,但对潜在的PTSD-PP的考虑具有无疑的临床相关性。事实上,它可以帮助从业者精确对急性精神病发作后康复患者的症状学分析;影响精神病的预后,考虑对生活质量以及情感和自杀共病的损害;并修改精神分裂症康复中的治疗方法。此外,关于精神病康复的文献似乎与“创伤后成长”(PTG)的概念特别相关。将精神病发作置于创伤框架中需要一种尽可能贴近患者体验主观性的临床方法,而不仅仅是评估精神病症状及其缓解情况。应用于PTSD-PP的以创伤为重点的治疗问题为未来研究开辟了领域。

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