Rizk M S, Zakhari N A, Walash M I, Toubar S S, Brooks C J, Anderson R
Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Egypt.
Acta Pharm Nord. 1991;3(4):205-10.
Metabolites isolated from human plasma after oral administration of norethisterone were assayed as their novel dimethylethylsilyl ether derivatives by gas chromatography--mass spectrometry--ion selective monitoring. The major metabolite is 3 alpha, 5 alpha-tetrahydronorethisterone. The unchanged drug is present in a measurable amount even after 8 h of drug administration. The method is accurate, precise and highly sensitive.
口服炔诺酮后从人血浆中分离出的代谢物，通过气相色谱 - 质谱 - 离子选择性监测，作为其新型二甲基乙基硅醚衍生物进行测定。主要代谢物是3α,5α - 四氢炔诺酮。即使在给药8小时后，仍可检测到未变化的药物。该方法准确、精密且高度灵敏。
