Guze B H, Hoffman J M, Baxter L R, Mazziotta J C, Phelps M E
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Alzheimer Dis Assoc Disord. 1991 Winter;5(4):215-30. doi: 10.1097/00002093-199100540-00001.
Alzheimer disease is a common neurodegenerative disorder consisting of memory impairment and intellectual function that produces not only profound disabilities in the patient, but a significant cost to society as well. The biochemical basis for Alzheimer disease is not completely understood, but both positron-emission tomography and single-photon-emission computed tomography provide insights into the in vivo biochemistry associated with this disease. Both techniques show characteristic brain abnormalities, which consist of reductions in temporal-parietal metabolism that progress in severity and extent as the disease itself shows clinical progression. Such noninvasive biochemical assays may ultimately prove to be of assistance in clinical management, and are clearly helpful in understanding the pathophysiologic mechanisms associated with the production of this disease.
阿尔茨海默病是一种常见的神经退行性疾病，表现为记忆障碍和智力功能减退，不仅给患者带来严重残疾，也给社会造成巨大经济负担。虽然阿尔茨海默病的生化基础尚未完全明确，但正电子发射断层扫描和单光子发射计算机断层扫描都有助于了解与该疾病相关的体内生物化学过程。这两种技术均显示出特征性的脑部异常，表现为颞顶叶代谢降低，且随着疾病临床进展，其严重程度和范围也会加重。这种非侵入性生化检测最终可能有助于临床管理，且对于理解该疾病发生的病理生理机制显然具有重要意义。
