Cutler N R, Haxby J V, Duara R, Grady C L, Kay A D, Kessler R M, Sundaram M, Rapoport S I
Ann Neurol. 1985 Sep;18(3):298-309. doi: 10.1002/ana.410180305.
Data concerning 7 patients with a diagnosis of presumptive Alzheimer's disease (mean age, 65.6 years) are presented in detail in relation to the patients' regional cerebral metabolic rates for glucose. Rates were measured by positron emission tomography with fluorine 18-labeled fluoro-2-deoxy-D-glucose under conditions of reduced visual and auditory stimulation. A relationship was found between severity of dementia and brain metabolism. In patients with mild to moderate Alzheimer's disease, memory and intellectual deficits were evident without major reductions in absolute metabolic rates, while ratios of regional to whole brain metabolism revealed reductions in regions of the parietal lobes. In the late, severe form of the disease, brain metabolic rates were consistently and significantly reduced. The findings suggest that memory and intellectual deficits are reflected in reductions of brain metabolism in some brain regions in mild to moderate forms of Alzheimer's disease and that, in the late, severe form of the disease, reductions occur consistently throughout the brain.
详细介绍了7例诊断为疑似阿尔茨海默病患者（平均年龄65.6岁）的相关数据，这些数据与患者大脑各区域的葡萄糖代谢率有关。在视觉和听觉刺激减少的条件下，通过正电子发射断层扫描术，使用氟18标记的氟代-2-脱氧-D-葡萄糖来测量代谢率。研究发现痴呆严重程度与脑代谢之间存在关联。在轻度至中度阿尔茨海默病患者中，记忆和智力缺陷明显，但绝对代谢率没有大幅降低，而区域代谢与全脑代谢的比率显示顶叶区域代谢降低。在疾病晚期、严重阶段，脑代谢率持续且显著降低。这些发现表明，在轻度至中度阿尔茨海默病中，记忆和智力缺陷反映在某些脑区的脑代谢降低上，而在疾病晚期、严重阶段，全脑代谢持续降低。
