Jørgensen P H, Bak B, Andreassen T T
Department of Connective Tissue Biology, University of Aarhus, Denmark.
Bone. 1991;12(5):353-9. doi: 10.1016/8756-3282(91)90022-b.
The influence of biosynthetic human growth hormone (b-hGH) on female rat cortical femur and tibia was studied after administration of hormone doses of 0.16, 1.10, or 8.33 mg/kg body weight/day for 90 days. The mechanical properties, dimensions, real density, ash weight, and the mineral and collagen concentrations of the bones were measured. In both femur and tibia a positive linear relation was found between the dose of hormone and ultimate load, ultimate stiffness, energy absorption at ultimate load, load at failure, energy absorption at failure, and deflection at failure. In the femur a positive correlation between dose and deflection at ultimate load was also found. After normalizing the mechanical data for the dimensions of the bones, no differences were found in the hormone treated groups compared to placebo, except for the elastic modulus (Young's modulus), which was decreased in the femur in the group given 8.33 mg b-hGH. The mineral and collagen concentration were unaffected in both femur and tibia, whereas the real density was decreased in the femur. The growth-hormone-induced changes in the mechanical properties seem to be caused mainly by increased dimensions of the bones.
研究了生物合成人生长激素（b-hGH）对雌性大鼠皮质股骨和胫骨的影响。给予大鼠体重剂量为0.16、1.10或8.33mg/kg/天的激素，持续90天。测量了骨骼的力学性能、尺寸、实际密度、灰分重量以及矿物质和胶原蛋白浓度。在股骨和胫骨中，激素剂量与极限载荷、极限刚度、极限载荷下的能量吸收、破坏载荷、破坏时的能量吸收以及破坏时的挠度之间均呈正线性关系。在股骨中，还发现剂量与极限载荷下的挠度呈正相关。将力学数据按骨骼尺寸进行归一化处理后，与安慰剂组相比，激素治疗组未发现差异，但弹性模量（杨氏模量）除外，在给予8.33mg b-hGH的组中，股骨的弹性模量降低。股骨和胫骨中的矿物质和胶原蛋白浓度未受影响，而股骨的实际密度降低。生长激素引起的力学性能变化似乎主要是由骨骼尺寸增加所致。
