Bak B, Jørgensen P H, Andreassen T T
Department of Connective Tissue Biology, University of Aarhus, Denmark.
Bone. 1990;11(4):233-9. doi: 10.1016/8756-3282(90)90075-a.
The effects of biosynthetic human growth hormone on the biomechanical properties of healing tibial fractures and intact bones in the rat were studied after 20 and 40 days of healing. Growth hormone, 2.0 mg per kg per day, was given subcutaneously in two daily doses. Control animals were injected with a corresponding volume of saline. After 20 days of fracture healing, there were no differences in mechanical properties between the healing fractures and intact bones. After 40 days, the ultimate load and maximum stiffness of the fractures of the b-hGH injected animals had increased to more than 400% of the corresponding values of the saline injected animals, and ultimate stress and energy absorption at ultimate load had increased to 270% compared with the saline injected animals. Ultimate load, stiffness, and energy absorption of the intact bones increased in the b-hGH injected animals, but no differences were found in ultimate stress values or normalized energy, indicating that the changes in the intact bones were quantitative phenomena.
研究了生物合成人生长激素对大鼠愈合20天和40天的胫骨骨折及完整骨骼生物力学特性的影响。生长激素剂量为每天2.0毫克/千克，分两次皮下注射。对照动物注射相应体积的生理盐水。骨折愈合20天后，愈合骨折与完整骨骼的力学性能无差异。40天后，注射b-hGH动物骨折的极限载荷和最大刚度增加到注射生理盐水动物相应值的400%以上，极限应力和极限载荷下的能量吸收与注射生理盐水动物相比增加到270%。注射b-hGH动物完整骨骼的极限载荷、刚度和能量吸收增加，但极限应力值或归一化能量无差异，表明完整骨骼的变化是定量现象。
