Pemberton Trevor J, Mendoza Gustavo, Gee Jason, Patel Pragna I
Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
J Calif Dent Assoc. 2007 May;35(5):324-6, 328-33.
Inherited dental anomalies such as hypodontia, supernumerary teeth, enamel defects, and diastema are evident in large segments of most populations. Although treatment options for many of these conditions are ever improving, much remains to be understood about their etiology and pathophysiology. In this review, the authors hope to enthuse dental professionals into aiding the human geneticist by collaborating in studies seeking the underlying genetic cause of dental anomalies and referring patients presenting these conditions to the human geneticist.
诸如牙量不足、多生牙、牙釉质缺陷和牙间隙等遗传性牙齿异常在大多数人群的很大一部分中很明显。尽管针对其中许多病症的治疗选择在不断改善,但关于它们的病因和病理生理学仍有许多有待了解。在这篇综述中,作者希望激发牙科专业人员通过合作开展研究来帮助人类遗传学家寻找牙齿异常的潜在遗传原因,并将出现这些病症的患者转介给人类遗传学家。