Driver Jeffrey, Ross John, Mihlan Gary, Lunchick Curt, Landenberger Bryce
infoscientific.com, Inc., Manassas, VA 20111, USA.
Regul Toxicol Pharmacol. 2007 Nov;49(2):125-37. doi: 10.1016/j.yrtph.2007.06.007. Epub 2007 Jul 17.
Quantitative characterization of the penetration of chemical residues through various types and configurations of clothing is an important underpinning of mitigation strategies to reduce dermal exposure to occupational cohorts. The objective of the evaluation presented herein is the development of pesticide clothing penetration (or conversely protection) factors for single layer clothing (i.e., long-sleeved shirt, long pants; gloves are not included) based on dermal exposure monitoring data (passive dosimetry) included in the Environmental Protection Agency's Pesticide Handlers Exposure Database (PHED). The analysis of penetration per replicate was conducted by comparison of the inside and outside (total deposition), expressed as mug/cm(2), for each replicate pair of dermal dosimeters. Clothing penetration was investigated as a function of job classification, dosimetry sampling method, body part, application method, and type of formulation. Grand mean single layer clothing penetration values for patch (n=2029) and whole-body (n=100) dosimeter samples from PHED were 12.12 (SE=0.33; SD=15.02) and 8.21 (SE=1.01; SD=10.14) percent, respectively. Linear regression was used to evaluate clothing penetration as a function of outer dosimeter loading. The regression analysis supports the hypothesis that single layer clothing penetration increases with decreasing outer dosimeter loading.
对化学残留物透过各类衣物类型及配置的渗透情况进行定量表征，是减少职业人群皮肤暴露的缓解策略的重要基础。本文所呈现评估的目标是，基于美国环境保护局农药处理人员暴露数据库（PHED）中包含的皮肤暴露监测数据（被动剂量测定法），为单层衣物（即长袖衬衫、长裤；不包括手套）制定农药衣物渗透（或相反的防护）因子。每次重复的渗透分析是通过比较每对皮肤剂量计复制品的内部和外部（总沉积量）来进行的，单位为微克/平方厘米。研究了衣物渗透与工作分类、剂量测定采样方法、身体部位、施用方法和制剂类型之间的关系。来自PHED的贴片（n = 2029）和全身（n = 100）剂量计样本的单层衣物渗透值的总体均值分别为12.12%（标准误 = 0.33；标准差 = 15.02）和8.21%（标准误 = 1.01；标准差 = 10.14）。采用线性回归来评估衣物渗透与外部剂量计负载量之间的关系。回归分析支持了单层衣物渗透随外部剂量计负载量降低而增加这一假设。
