[口腔扁平苔藓中热休克蛋白60和热休克蛋白70的研究]
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus].
作者信息
Di Ping, Gao Yan
机构信息
Center of Implantation, Peking University School of Stomatology, Beijing 100081, China.
出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2003 Jul;38(4):275-8.
OBJECTIVE
To study the role of heat shock protein (HSP) 60 and HSP70 in the pathogenesis of oral lichen planus (OLP).
METHODS
The immunohistochemical SP methods were used to detected the expression of HSP60 and HSP70 in 62 cases of oral lichen planus, 10 cases of normal oral mucosa, 21 cases of chronic discoid lupus erythematosus (DLE), 10 cases of benign lymphoadenosis of mucosa, 46 cases of leukoplakia. RT-PCR was used to evaluate the expression of HSP60 mRNA and HSP70 mRNA in 12 cases of OLP and 5 cases of normal oral mucosa.
RESULTS
HSP60 was expressed at much higher levels in OLP than other groups. The expression of HSP70 decreased in epithelial cells in erosive lichen planus group. HSP60 mRNA and HSP70 mRNA were expressed at high level in OLP.
CONCLUSION
HSP60 and HSP70 play an important role in pathogenesis of OLP.
目的
研究热休克蛋白（HSP）60和HSP70在口腔扁平苔藓（OLP）发病机制中的作用。
方法
采用免疫组织化学SP法检测62例口腔扁平苔藓、10例正常口腔黏膜、21例慢性盘状红斑狼疮（DLE）、10例黏膜良性淋巴组织增生症、46例白斑中HSP60和HSP70的表达。采用逆转录-聚合酶链反应（RT-PCR）检测12例OLP和5例正常口腔黏膜中HSP60 mRNA和HSP70 mRNA的表达。
结果
HSP60在OLP中的表达水平远高于其他组。糜烂型扁平苔藓组上皮细胞中HSP70表达降低。OLP中HSP60 mRNA和HSP70 mRNA表达水平较高。
结论
HSP60和HSP70在OLP发病机制中起重要作用。
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