2,3-二芳基-1,3-噻唑烷-4-酮衍生物作为选择性环氧化酶（COX-2）抑制剂的合成
Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.
作者信息
Zarghi Afshin, Najafnia Leila, Daraee Bahram, Dadrass Orkideh G, Hedayati Mehdi
机构信息
Department of Pharmaceutical Chemistry, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Bioorg Med Chem Lett. 2007 Oct 15;17(20):5634-7. doi: 10.1016/j.bmcl.2007.07.084. Epub 2007 Aug 22.
PMID:17822894
Abstract
A group of 2,3-diaryl-1,3-thiazolidine-4-ones, possessing a methylsulfonyl pharmacophore, were synthesized and their biological activities were evaluated for cyclooxygenase-2 (COX-2) inhibitory activity.
摘要
合成了一组具有甲磺酰基药效团的2,3-二芳基-1,3-噻唑烷-4-酮，并对其环氧合酶-2（COX-2）抑制活性进行了生物活性评估。
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