单体素¹H磁共振波谱在胶质瘤进展中的应用

Monovoxel 1H magnetic resonance spectroscopy in the progression of gliomas.

作者信息

Alimenti Alessandro, Delavelle Jacqueline, Lazeyras François, Yilmaz Hasan, Dietrich Pierre-Yves, de Tribolet Nicolas, Lövblad Karl-Olof

机构信息

Department of Radiology, Geneva University Hospital, Geneva, Switzerland.

出版信息

Eur Neurol. 2007;58(4):198-209. doi: 10.1159/000107940. Epub 2007 Sep 7.

DOI:10.1159/000107940

PMID:17823533

Abstract

AIM

Can monovoxel magnetic resonance spectroscopy (MRS) reliably follow tumour progression in low-grade glioma?

MATERIALS AND METHODS

21 patients with low-grade glioma underwent at least 3 MRS.

RESULTS

For progression from a grade II to grade III tumour, a sensitivity of 57.1% and specificity of 60% were observed, with a positive predictive value (PPV) of 48.8% and a negative predictive value (NPV) of 54.5%. For progression under treatment, we obtained a sensitivity of 57.1% by N-acetylaspartate (NAA)/choline (Cho) and myoinositol/creatine (Cr) and a specificity of 100% by Cho/Cr and lipids, with a PPV of 80% and a NPV of 63.6%.

CONCLUSION

We found that NAA/Cho is the best marker of tumour progression before therapy, with a sensitivity of 53.9%. For the therapeutic response, sensitivity was only 28.2%.

摘要

目的

单体素磁共振波谱（MRS）能否可靠地跟踪低级别胶质瘤的肿瘤进展？

材料与方法

21例低级别胶质瘤患者接受了至少3次MRS检查。

结果

对于从二级肿瘤进展为三级肿瘤，观察到的敏感度为57.1%，特异度为60%，阳性预测值（PPV）为48.8%，阴性预测值（NPV）为54.5%。对于治疗过程中的进展，通过N-乙酰天门冬氨酸（NAA）/胆碱（Cho）和肌醇/肌酸（Cr）得出的敏感度为57.1%，通过Cho/Cr和脂质得出的特异度为100%，PPV为80%，NPV为63.6%。