Chaumeil Myriam M, Lupo Janine M, Ronen Sabrina M
Department of Radiology and Biomedical Imaging, Mission Bay Campus.
Brain Tumor Research Center, University of California, San Francisco, CA.
Brain Pathol. 2015 Nov;25(6):769-80. doi: 10.1111/bpa.12310.
This review is focused on describing the use of magnetic resonance (MR) spectroscopy for metabolic imaging of brain tumors. We will first review the MR metabolic imaging findings generated from preclinical models, focusing primarily on in vivo studies, and will then describe the use of metabolic imaging in the clinical setting. We will address relatively well-established (1) H MRS approaches, as well as (31) P MRS, (13) C MRS and emerging hyperpolarized (13) C MRS methodologies, and will describe the use of metabolic imaging for understanding the basic biology of glioma as well as for improving the characterization and monitoring of brain tumors in the clinic.
本综述聚焦于描述磁共振（MR）波谱在脑肿瘤代谢成像中的应用。我们将首先回顾临床前模型产生的MR代谢成像结果，主要关注体内研究，然后描述代谢成像在临床环境中的应用。我们将探讨相对成熟的（1）H MRS方法，以及（31）P MRS、（13）C MRS和新兴的超极化（13）C MRS方法，并描述代谢成像在理解胶质瘤基本生物学以及改善临床脑肿瘤的特征描述和监测方面的应用。
