Kerr A Ross, Katz Ronald W, Ship Jonathan A
Department of Oral and Maxillofacial Pathology, Radiology and Medicine, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010, USA.
Quintessence Int. 2007 Sep;38(8):e440-7.
To determine if 2 commercial mouthrinses, 1 alcohol-based and 1 nonalcohol-based, affect salivary flow and symptoms of dry mouth in nonxerostomic adults.
This observer-blinded, randomized, crossover pilot study involved 20 adults. The primary endpoints of interest were whole salivary flow rates and the perceived mouth dryness VAS scores following 1 week of use. ANOVA was used to determine differences in these endpoints between groups, and ANCOVA was used to control for any variation in baseline flow rates and VAS scores (P <.05).
There were no significant differences between groups at baseline. After 1 week of mouthrinse use, ANOVA and ANCOVA of combined data (before and after crossover) revealed no significant differences in either flow rates or VAS scores between groups (P >.05).
There were no differences in objective or subjective measures of mouth dryness between alcohol- and nonalcohol-containing mouthrinses after 1 week in nonxerostomic subjects.
确定两种市售漱口水（一种含酒精，一种不含酒精）对非口干症成年人唾液流量和口干症状的影响。
这项观察者盲法、随机、交叉试验性研究纳入了20名成年人。主要关注的终点是使用1周后的全唾液流速和主观口干视觉模拟评分（VAS）。采用方差分析来确定组间这些终点的差异，并采用协方差分析来控制基线流速和VAS评分的任何变化（P<.05）。
基线时组间无显著差异。使用漱口水1周后，对合并数据（交叉前后）进行方差分析和协方差分析显示，组间流速或VAS评分均无显著差异（P>.05）。
在非口干症受试者中，含酒精和不含酒精的漱口水使用1周后，在口干的客观或主观测量方面没有差异。
