Riep B G, Bernimoulin J P, Barnett M L
Department of Periodontology, Humboldt University/Charité, Berlin, Germany.
J Clin Periodontol. 1999 Mar;26(3):164-8. doi: 10.1034/j.1600-051x.1999.260306.x.
The adjunctive use of antimicrobial mouthrinses to help control supragingival plaque and gingivitis has been shown to contribute significantly to patients' daily oral hygiene regimens. This controlled clinical study used an observer-blind, randomized, cross-over design in a 4-day plaque regrowth model to determine the relative efficacies of an essential oil-containing mouthrinse (Listerine Antiseptic) and an amine fluoride/stannous fluoride-containing mouthrinse (Meridol) in inhibiting the development of supragingival plaque. A 0.1% chlorhexidine mouthrinse (Chlorhexamed-Fluid) was used as a positive control, and a 5% hydroalcohol solution was used as a negative control. Dosing for each of the test mouthrinses was based on the manufacturers' label directions. Because the volume and rinse time for each of the test mouthrinses were different, each test mouthrinse had its own negative control group. On day 1 of each test period, subjects received an oral soft and hard tissue examination and a dental prophylaxis to remove all plaque, calculus, and extrinsic stain. Starting the same day, subjects refrained from all mechanical oral hygiene procedures for the next 4 days and rinsed 2x daily under supervision with their randomly-assigned mouthrinse. On day 5, each subject received a plaque assessment as well as an oral examination to assess side effects. Each test period was separated by a 2-week washout period. 23 volunteers with a median age of 26 years completed the study. Compared to the respective placebos, the median percent plaque reductions at 5 days were 23.0%, 12.2%, and 38.2% for the essential oil, amine/stannous fluoride, and chlorhexidine rinses, respectively. The plaque reductions seen in the essential oil and chlorhexidine rinse groups were statistically significant (p < 0.001), while the plaque reduction in the amine/stannous fluoride rinse group was not statistically significant (p > 0.05). Additionally, the essential oil rinse was significantly more effective (p < 0.001) than the amine/stannous fluoride rinse in inhibiting plaque accumulation in this clinical model.
抗菌漱口水辅助用于帮助控制龈上菌斑和牙龈炎，已被证明对患者的日常口腔卫生方案有显著贡献。这项对照临床研究在4天的菌斑再生长模型中采用观察者盲法、随机、交叉设计，以确定含精油漱口水（李施德林抗菌漱口水）和含胺氟化物/氟化亚锡漱口水（美利道）在抑制龈上菌斑形成方面的相对疗效。0.1%氯己定漱口水（洗必泰液）用作阳性对照，5%乙醇溶液用作阴性对照。每种测试漱口水的给药均基于制造商的标签说明。由于每种测试漱口水的用量和漱口时间不同，每种测试漱口水都有自己的阴性对照组。在每个测试期的第1天，受试者接受口腔软组织和硬组织检查以及牙齿洁治，以清除所有菌斑、牙石和外源性污渍。从同一天开始，受试者在接下来的4天内避免所有机械性口腔卫生程序，并在监督下每天用随机分配的漱口水漱口2次。在第5天，对每个受试者进行菌斑评估以及口腔检查以评估副作用。每个测试期之间间隔2周的洗脱期。23名年龄中位数为26岁的志愿者完成了该研究。与各自的安慰剂相比，精油、胺/氟化亚锡和氯己定漱口水在第5天的菌斑减少中位数分别为23.0%、12.2%和38.2%。精油和氯己定漱口水组的菌斑减少具有统计学意义（p<0.001），而胺/氟化亚锡漱口水组的菌斑减少无统计学意义（p>0.05）。此外，在该临床模型中，精油漱口水在抑制菌斑积聚方面比胺/氟化亚锡漱口水显著更有效（p<0.001）。
