• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从分子到诊断工具：环形泰勒虫表面蛋白TaSP

From molecule to diagnostic tool: Theileria annulata surface protein TaSP.

作者信息

Seitzer Ulrike, Bakheit Mohammed A, Salih Dia Eldin A, Ali Awadia, Haller Daniel, Yin Hong, Schnittger Leonhard, Ahmed Jabbar

机构信息

Veterinary Infection Biology and Immunology, Research Center Borstel, Parkallee 22, 23845, Borstel, Germany.

出版信息

Parasitol Res. 2007 Sep;101 Suppl 2:S217-23. doi: 10.1007/s00436-007-0685-6.

DOI:10.1007/s00436-007-0685-6
PMID:17823831
Abstract

Isolation and characterization of the Theileria annulata macroshizont stage protein TaSP showed that this parasite surface membrane protein is a highly antigenic protein suitable for the development of diagnostic tools for tropical theileriosis. An enzyme-linked immunosorbent assay (ELISA) for the detection of circulating antibodies against Theileria annulata was established and validated using the recombinantly expressed TaSP protein. The ELISA has subsequently been applied for cross-sectional surveys to determine the distribution and prevalence of tropical theileriosis in Sudan.

摘要

环形泰勒虫大裂殖体阶段蛋白TaSP的分离与特性分析表明，这种寄生虫表面膜蛋白是一种高度抗原性的蛋白，适合用于开发热带泰勒虫病的诊断工具。利用重组表达的TaSP蛋白建立并验证了一种用于检测抗环形泰勒虫循环抗体的酶联免疫吸附测定（ELISA）。该ELISA随后被应用于横断面调查，以确定苏丹热带泰勒虫病的分布和流行情况。

相似文献

1
From molecule to diagnostic tool: Theileria annulata surface protein TaSP.从分子到诊断工具：环形泰勒虫表面蛋白TaSP
Parasitol Res. 2007 Sep;101 Suppl 2:S217-23. doi: 10.1007/s00436-007-0685-6.
2
Application of the recombinant Theileria annulata surface protein in an indirect ELISA for the diagnosis of tropical theileriosis.重组环形泰勒虫表面蛋白在间接ELISA诊断热带泰勒虫病中的应用。
Parasitol Res. 2004 Mar;92(4):299-302. doi: 10.1007/s00436-003-1055-7. Epub 2004 Jan 13.
3
Characterization of a polymorphic Theileria annulata surface protein (TaSP) closely related to PIM of Theileria parva: implications for use in diagnostic tests and subunit vaccines.与小泰勒虫PIM密切相关的多态性环形泰勒虫表面蛋白（TaSP）的特性：对诊断测试和亚单位疫苗应用的意义。
Mol Biochem Parasitol. 2002 Apr 9;120(2):247-56. doi: 10.1016/s0166-6851(02)00013-0.
4
Validation of the indirect TaSP enzyme-linked immunosorbent assay for diagnosis of Theileria annulata infection in cattle.间接TaSP酶联免疫吸附测定法用于诊断牛环形泰勒虫感染的验证
Parasitol Res. 2005 Oct;97(4):302-8. doi: 10.1007/s00436-005-1431-6. Epub 2005 Jul 29.
5
Comparisons among two serological tests and microscopic examination for the detection of Theileria annulata in cattle in northern Sudan.苏丹北部牛环形泰勒虫检测中两种血清学检测方法与显微镜检查的比较
Prev Vet Med. 2007 Oct 16;81(4):323-6. doi: 10.1016/j.prevetmed.2007.05.008. Epub 2007 Jun 27.
6
Evaluation of Theileria annulata recombinant immunodominant proteins for the development of ELISA.用于酶联免疫吸附测定（ELISA）开发的环形泰勒虫重组免疫显性蛋白的评估
Transbound Emerg Dis. 2008 Aug;55(5-6):244-8. doi: 10.1111/j.1865-1682.2008.01030.x.
7
Development of a competitive ELISA for detection of Theileria annulata infection.用于检测环形泰勒虫感染的竞争性酶联免疫吸附测定法的开发。
Transbound Emerg Dis. 2008 Aug;55(5-6):249-56. doi: 10.1111/j.1865-1682.2008.01036.x.
8
Evaluation of sporozoite and macroschizont antigen (Spm2) of Theileria annulata for its diagnostic potential.评估环形泰勒虫裂殖子和大配子体抗原（Spm2）的诊断潜力。
Ticks Tick Borne Dis. 2021 Jul;12(4):101691. doi: 10.1016/j.ttbdis.2021.101691. Epub 2021 Feb 19.
9
Development of a recombinant TaSP-based Dot-ELISA for detection of Theileria annulata infection in cattle.基于 TaSP 的重组 Dot-ELISA 的研制及其在牛环形泰勒虫感染检测中的应用。
Ticks Tick Borne Dis. 2018 Sep;9(6):1416-1420. doi: 10.1016/j.ttbdis.2018.06.016. Epub 2018 Jun 30.
10
Comparative diagnostic performance of recombinant Tams1 protein based dot-ELISA in detecting tropical theileriosis in naturally infected cattle.基于重组Tams1蛋白的斑点酶联免疫吸附测定法在检测自然感染牛的热带泰勒虫病中的比较诊断性能
Sci Rep. 2025 Jan 2;15(1):431. doi: 10.1038/s41598-024-84892-1.

引用本文的文献

1
Comparative diagnostic performance of recombinant Tams1 protein based dot-ELISA in detecting tropical theileriosis in naturally infected cattle.基于重组Tams1蛋白的斑点酶联免疫吸附测定法在检测自然感染牛的热带泰勒虫病中的比较诊断性能
Sci Rep. 2025 Jan 2;15(1):431. doi: 10.1038/s41598-024-84892-1.
2
A novel recombinant surface protein as an antigen in indirect enzyme-linked immunosorbent assay for the serological diagnosis of tropical theileriosis.一种新型重组表面蛋白作为抗原用于热带泰勒虫病血清学诊断的间接酶联免疫吸附测定。
Vet World. 2024 Aug;17(8):1936-1942. doi: 10.14202/vetworld.2024.1936-1942. Epub 2024 Aug 27.
3

本文引用的文献

1
Epidemiology of Theileria annulata infection of dairy cattle in the Sudan using molecular techniques.采用分子技术对苏丹奶牛环形泰勒虫感染情况进行的流行病学研究
Ann N Y Acad Sci. 2006 Oct;1081:471-2. doi: 10.1196/annals.1373.068.
2
Identification of homologous genes of T. annulata proteins in the genome of Theileria sp. (China).在环形泰勒虫（中国株）基因组中鉴定环形泰勒虫蛋白质的同源基因。
Ann N Y Acad Sci. 2006 Oct;1081:468-70. doi: 10.1196/annals.1373.067.
3
Identification of potential antigenic proteins of Theileria lestoquardi.莱氏泰勒虫潜在抗原蛋白的鉴定
Multiplex ddPCR: A Promising Diagnostic Assay for Early Detection and Drug Monitoring in Bovine Theileriosis.
多重数字滴液PCR：牛泰勒虫病早期检测和药物监测的一种有前景的诊断检测方法。
Pathogens. 2023 Feb 10;12(2):296. doi: 10.3390/pathogens12020296.
4
An endpoint visualization loop-mediated isothermal amplification (LAMP) for detecting bubaline theileriosis.用于检测水牛泰勒虫病的终点可视化环介导等温扩增（LAMP）
Beni Suef Univ J Basic Appl Sci. 2022;11(1):67. doi: 10.1186/s43088-022-00251-x. Epub 2022 May 13.
5
Identification of Theileria spp. and investigation of hematological profiles of their infections in goats in Hainan Island, China.鉴定中国海南岛山羊泰勒虫属感染及其血液学特征调查。
Parasite. 2022;29:13. doi: 10.1051/parasite/2022013. Epub 2022 Mar 7.
6
Clinical and Pathological Studies on Cattle Experimentally Infected with in China.中国牛实验感染[病原体名称未给出]的临床与病理学研究
Pathogens. 2020 Sep 3;9(9):727. doi: 10.3390/pathogens9090727.
7
A Real-Time PCR based assay for determining parasite to host ratio and parasitaemia in the clinical samples of Bovine Theileriosis.基于实时 PCR 的检测方法，用于确定牛泰勒虫病临床样本中的寄生虫与宿主的比例和寄生虫血症。
Sci Rep. 2018 Oct 18;8(1):15441. doi: 10.1038/s41598-018-33721-3.
8
Evaluating an indirect rMPSP enzyme-linked immunosorbent assay for the detection of bovine Theileria infection in China.评估一种间接重组微小牛蜱分泌蛋白酶联免疫吸附测定法在中国用于检测牛泰勒虫感染的情况。
Parasitol Res. 2017 Feb;116(2):667-676. doi: 10.1007/s00436-016-5332-7. Epub 2016 Dec 10.
9
Seroprevalence of bovine theileriosis in northern China.中国北方牛泰勒虫病血清流行率
Parasit Vectors. 2016 Nov 18;9(1):591. doi: 10.1186/s13071-016-1882-x.
10
Identification and Analysis of Immunodominant Antigens for ELISA-Based Detection of Theileria annulata.基于酶联免疫吸附测定法检测环形泰勒虫的免疫显性抗原的鉴定与分析
PLoS One. 2016 Jun 7;11(6):e0156645. doi: 10.1371/journal.pone.0156645. eCollection 2016.
Ann N Y Acad Sci. 2006 Oct;1081:463-4. doi: 10.1196/annals.1373.065.
4
Development of a recombinant indirect ELISA for the diagnosis of Theileria sp. (China) infection in small ruminants.用于诊断小反刍动物泰勒虫（中国株）感染的重组间接ELISA检测方法的建立
Parasitol Res. 2006 May;98(6):561-7. doi: 10.1007/s00436-005-0105-8. Epub 2006 Jan 20.
5
A new recombinant protein-based ELISA for the diagnosis of malignant theileriosis of sheep and goats.一种用于诊断绵羊和山羊恶性泰勒虫病的新型基于重组蛋白的酶联免疫吸附测定法。
Parasitol Res. 2006 Jan;98(2):145-9. doi: 10.1007/s00436-005-0034-6. Epub 2005 Nov 18.
6
Validation of the indirect TaSP enzyme-linked immunosorbent assay for diagnosis of Theileria annulata infection in cattle.间接TaSP酶联免疫吸附测定法用于诊断牛环形泰勒虫感染的验证
Parasitol Res. 2005 Oct;97(4):302-8. doi: 10.1007/s00436-005-1431-6. Epub 2005 Jul 29.
7
Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes.牛淋巴细胞转化病原体——微小泰勒虫的基因组序列
Science. 2005 Jul 1;309(5731):134-7. doi: 10.1126/science.1110439.
8
Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.与小泰勒虫相比，宿主细胞转化寄生虫环形泰勒虫的基因组
Science. 2005 Jul 1;309(5731):131-3. doi: 10.1126/science.1110418.
9
Preliminary survey of ticks (Acari: Ixodidae) on cattle in northern Sudan.苏丹北部牛身上蜱虫（蜱螨亚纲：硬蜱科）的初步调查
Onderstepoort J Vet Res. 2004 Dec;71(4):319-26. doi: 10.4102/ojvr.v71i4.252.
10
Identification of antigenic proteins of a Theileria species pathogenic for small ruminants in China recognized by antisera of infected animals.鉴定中国感染小反刍动物的泰勒虫物种的抗原蛋白，这些蛋白可被感染动物的抗血清识别。
Ann N Y Acad Sci. 2004 Oct;1026:161-4. doi: 10.1196/annals.1307.024.