甘草酸对去甲乌药碱光转化的影响。
Effect of glycyrrhizic acid on lappaconitine phototransformation.
作者信息
Kornievskaya Valeria S, Kruppa Alexander I, Polyakov Nicholas E, Leshina Tatyana V
机构信息
Institute of Chemical Kinetics and Combustion, Institutskaya str. 3, Novosibirsk, 630090, Russia.
出版信息
J Phys Chem B. 2007 Oct 4;111(39):11447-52. doi: 10.1021/jp0739770. Epub 2007 Sep 8.
1H NMR and CIDNP methods were used to demonstrate that triterpene glycoside (glycyrrhizic acid, GA) can substantially change the efficiency and direction of phototransformation of alkaloid lappaconitine (LA) due to both its solubilization in GA micelles and protonation of LA amine nitrogen in water-alcohol solutions. The LA solubilization in the GA micelle suppresses the process of deacylation.
采用¹H NMR和CIDNP方法证明，三萜糖苷（甘草酸，GA）可显著改变生物碱拉帕替尼（LA）的光转化效率和方向，这是由于其在GA胶束中的增溶作用以及在水 - 醇溶液中LA胺氮的质子化作用。LA在GA胶束中的增溶作用抑制了脱酰基过程。
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