Tuteja Renu
Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
FEBS J. 2007 Sep;274(18):4699-704. doi: 10.1111/j.1742-4658.2007.06000.x.
Of the four Plasmodium species that cause human malaria, Plasmodium falciparum is responsible for the most severe form of the disease and this parasite is developing resistance to the major antimalarial drugs. Therefore, in order to control malaria it is necessary to identify new drug targets. One feasible target might be helicases, which are important unwinding enzymes and required for almost all the nucleic acid metabolism in the malaria parasite.
在导致人类疟疾的四种疟原虫中，恶性疟原虫会引发最严重的疟疾形式，并且这种寄生虫正在对主要抗疟药物产生耐药性。因此，为了控制疟疾，有必要确定新的药物靶点。一种可行的靶点可能是解旋酶，它是重要的解旋酶，几乎是疟原虫所有核酸代谢所必需的。
