Norman S B, Stein M B, Dimsdale J E, Hoyt D B
Department of Psychiatry, University of California, San Diego, CA 92103, USA.
Psychol Med. 2008 Apr;38(4):533-42. doi: 10.1017/S0033291707001389. Epub 2007 Sep 10.
Identifying risk factors for the development of post-traumatic stress disorder (PTSD) is important for understanding and ultimately preventing the disorder. This study assessed pain shortly after traumatic injury (i.e. peritraumatic pain) as a risk factor for PTSD.
Participants (n=115) were patients admitted to a Level 1 Surgical Trauma Center. Admission to this service reflected a severe physical injury requiring specialized, emergent trauma care. Participants completed a pain questionnaire within 48 h of traumatic injury and a PTSD diagnostic module 4 and 8 months later.
Peritraumatic pain was associated with an increased risk of PTSD, even after controlling for a number of other significant risk factors other than acute stress disorder symptoms. An increase of 0.5 s.d. from the mean in a 0-10 pain rating scale 24-48 h after injury was associated with an increased odds of PTSD at 4 months by more than fivefold, and at 8 months by almost sevenfold. A single item regarding amount of pain at the time of hospital admission correctly classified 65% of participants.
If these findings are replicated in other samples, high levels of peritraumatic pain could be used to identify individuals at elevated risk for PTSD following traumatic injury.
识别创伤后应激障碍(PTSD)发生的风险因素对于理解并最终预防该疾病至关重要。本研究评估创伤性损伤后不久的疼痛(即创伤周围疼痛)作为PTSD的一个风险因素。
参与者(n = 115)为入住一级外科创伤中心的患者。入住该科室表明存在需要专业紧急创伤护理的严重身体损伤。参与者在创伤性损伤后48小时内完成一份疼痛问卷,并在4个月和8个月后完成一份PTSD诊断模块。
即使在控制了除急性应激障碍症状之外的许多其他重要风险因素后,创伤周围疼痛仍与PTSD风险增加相关。在受伤后24 - 48小时,0 - 10疼痛评分量表上比平均水平增加0.5标准差,与4个月时PTSD几率增加超过五倍以及8个月时增加近七倍相关。关于入院时疼痛程度的单个项目正确分类了65%的参与者。
如果这些发现在其他样本中得到重复,高水平的创伤周围疼痛可用于识别创伤性损伤后PTSD风险升高的个体。