[中国南方 HLA - A、B 和 DRB1 等位基因多态性与鼻咽癌的相关性]
[Correlation of the polymorphism of HLA-A, B and DRB1 alleles with nasopharyngeal carcinoma in the south of China].
作者信息
Zeng Xue-hui, Xiao Lu-lu, Li Jiang, Lu Jian-xin, Wang Xiao-ning
机构信息
Institute of Cellular and Molecular Medicine, Key Laboratory of Medical Genetics of Zhejiang Provincial, Wenzhou Medical College, Wenzhou 325035, China.
出版信息
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Sep;23(9):819-20.
AIM
To explore the correlation between and nasopharyngeal carcinoma the polymorphism of HLA-A, B and DRB1 alleles in the south of China.
METHODS
The genotypes of HLA-A, B and DRB1 alleles in 35 patients with NPC and 60 healthy controls were determined by PCR-sequence-specific primer (PCR-SSP).
RESULTS
The frequency of HLA-A * 02, HLA-B * 58 and HLA-DRB1 * 03 in the patients with NPC was higher than that in healthy controls (P < 0.05) while the frequency of HLAB * 40 was lower than that in NPC patients (P<0.05).
CONCLUSION
HLA-A * 02, HLA-B * 58 and HLA-DRB1 * 03 might be the susceptible genes of NPC patients while HLA-B * 40 might be the protective gene of NPC patients.
目的
探讨中国南方鼻咽癌与HLA - A、B和DRB1等位基因多态性之间的相关性。
方法
采用聚合酶链反应-序列特异性引物（PCR - SSP）法检测35例鼻咽癌患者和60例健康对照者的HLA - A、B和DRB1等位基因的基因型。
结果
鼻咽癌患者中HLA - A * 02、HLA - B * 58和HLA - DRB1 * 03的频率高于健康对照者（P < 0.05），而HLA - B * 40的频率低于鼻咽癌患者（P < 0.05）。
结论
HLA - A * 02、HLA - B * 58和HLA - DRB1 * 03可能是鼻咽癌患者的易感基因，而HLA - B * 40可能是鼻咽癌患者的保护基因。
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