Roberts Alan, Li W-C, Soffe S R, Wolf Ervin
School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK.
Brain Res Rev. 2008 Jan;57(1):22-8. doi: 10.1016/j.brainresrev.2007.06.015. Epub 2007 Jul 27.
A long-standing hypotheses is that locomotion is turned on by descending excitatory synaptic drive. In young frog tadpoles, we show that prolonged swimming in response to a brief stimulus can be generated by a small region of caudal hindbrain and rostral spinal cord. Whole-cell patch recordings in this region identify hindbrain neurons that excite spinal neurons to drive swimming. Some of these hindbrain reticulospinal neurons excite each other. We consider how feedback excitation within the hindbrain may provide a mechanism to drive spinal locomotor networks.
一个长期存在的假说是，运动是由下行兴奋性突触驱动开启的。在幼蛙蝌蚪中，我们发现，一小片尾侧后脑和吻侧脊髓区域就能产生对短暂刺激做出反应的长时间游泳行为。该区域的全细胞膜片钳记录确定了能兴奋脊髓神经元以驱动游泳的后脑神经元。其中一些后脑网状脊髓神经元相互兴奋。我们探讨了后脑内的反馈兴奋如何可能提供一种驱动脊髓运动网络的机制。
