Krumbholz M, Theil D, Steinmeyer F, Cepok S, Hemmer B, Hofbauer M, Farina C, Derfuss T, Junker A, Arzberger T, Sinicina I, Hartle C, Newcombe J, Hohlfeld R, Meinl E
Department of Neuroimmunology, Max-Planck-Institute of Neurobiology, Am Klopferspitz 18, Martinsried, Germany.
J Neuroimmunol. 2007 Oct;190(1-2):72-9. doi: 10.1016/j.jneuroim.2007.07.024. Epub 2007 Sep 6.
CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response and establishing immunological tolerance. We report that in the normal human brain CCL19, but not CCL21, is transcribed, and detectable as a protein in tissue lysates and in cerebrospinal fluid. In both active and inactive multiple sclerosis (MS) lesions CCL19 transcripts were elevated. In cerebrospinal fluid from MS and OIND patients CCL19 protein was increased. In relapsing-remitting and secondary progressive MS patients CCL19 correlated with intrathecal IgG production. This study suggests that CCL19 plays a role in both the physiological immunosurveillance of the healthy CNS and the pathological maintenance of immune cells in the CNS of MS patients.
CCL19和CCL21与CCR7结合，CCR7对于诱导免疫反应和建立免疫耐受都至关重要。我们报告称，在正常人类大脑中，CCL19可转录，但CCL21不可转录，并且在组织裂解物和脑脊液中可检测到CCL19蛋白。在活动性和非活动性多发性硬化症（MS）病变中，CCL19转录本均升高。在MS和视神经脊髓炎谱系疾病（OIND）患者的脑脊液中，CCL19蛋白增加。在复发缓解型和继发进展型MS患者中，CCL19与鞘内IgG产生相关。本研究表明，CCL19在健康中枢神经系统（CNS）的生理免疫监视以及MS患者CNS中免疫细胞的病理维持中均发挥作用。
