Waag David M
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Vaccine. 2007 Oct 16;25(42):7288-95. doi: 10.1016/j.vaccine.2007.08.002. Epub 2007 Aug 20.
Designation as a Category B biothreat agent has propelled Coxiella burnetii from a relatively obscure, underappreciated, "niche" microorganism on the periphery of bacteriology, to one of possibly great consequence if actually used in acts of bioterrorism. Advances in the study of this microorganism proceeded slowly, primarily because of the difficulty in studying this obligate intracellular pathogen that must be manipulated under biosafety level-3 conditions. The dogged determination of past and current C. burnetii researchers and the application of modern immunological and molecular techniques have more clearly defined the host and bacterial response to infection. This review is intended to provide a basic introduction to C. burnetii and Q fever, while emphasizing immunomodulatory properties, both positive and negative, of Q fever vaccines and C. burnetii infections.
被指定为B类生物威胁因子，已将伯纳特柯克斯体从细菌学边缘一种相对 obscure、未得到充分重视的“小众”微生物，转变为若实际用于生物恐怖主义行为可能造成重大后果的微生物之一。对这种微生物的研究进展缓慢，主要是因为研究这种专性胞内病原体存在困难，必须在生物安全3级条件下进行操作。过去和现在的伯纳特柯克斯体研究人员的坚定决心以及现代免疫学和分子技术的应用，更清楚地界定了宿主和细菌对感染的反应。本综述旨在对伯纳特柯克斯体和Q热进行基本介绍，同时强调Q热疫苗和伯纳特柯克斯体感染的正负免疫调节特性。
