Karius D R, Ling L M, Speck D F
Department of Physiology, University of Kentucky Medical Center, Lexington 40536-0084.
Brain Res. 1991 Sep 13;559(1):22-8. doi: 10.1016/0006-8993(91)90282-z.
This study investigated a possible role of the rostral dorsolateral pons (including nucleus parabrachialis medialis and Kölliker-Fuse nucleus) in mediating several inspiratory inhibitions. These inhibitions included the transient inhibition of phrenic inspiratory motor output produced by stimulation of the superior laryngeal nerve (SLN), the intercostal nerve (ICN) or the phrenic nerve (PN), as well as the inspiratory termination produced by trains of stimuli delivered to the SLN or ICN. In decerebrate, paralyzed, and artificially ventilated cats, the inhibitions produced by stimulation of these nerves were observed before and after lesioning (either radiofrequency, n = 8, or electrolytic, n = 9) the dorsolateral pons. Delivery of stimulus trains to the SLN or the ICN continued to elicit inspiratory termination following pontine lesions with no significant change in the threshold. There were no significant effects of bilateral dorsolateral pontine lesions on the threshold, onset latency, or duration of the short-latency, transient inhibitions produced by SLN, ICN or PN stimulation. From these data, we conclude that the rostral dorsolateral pons is not required in the production of any of these inhibitory reflexes.
本研究调查了脑桥嘴侧背外侧区（包括臂旁内侧核和 Kölliker-Fuse 核）在介导多种吸气抑制中可能发挥的作用。这些抑制包括刺激喉上神经（SLN）、肋间神经（ICN）或膈神经（PN）所产生的膈神经吸气运动输出的短暂抑制，以及向 SLN 或 ICN 施加一连串刺激所产生的吸气终止。在去大脑、麻痹并进行人工通气的猫中，在损毁（射频损毁，n = 8；或电解损毁，n = 9）脑桥背外侧区之前和之后，观察这些神经刺激所产生的抑制。在脑桥损伤后，向 SLN 或 ICN 施加一连串刺激仍可引发吸气终止，阈值无显著变化。双侧脑桥背外侧区损伤对 SLN、ICN 或 PN 刺激所产生的短潜伏期、短暂抑制的阈值、起始潜伏期或持续时间均无显著影响。根据这些数据，我们得出结论，在产生这些抑制性反射中的任何一种时，均不需要脑桥嘴侧背外侧区。
