Oku Y, Dick T E
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
J Appl Physiol (1985). 1992 Feb;72(2):721-30. doi: 10.1152/jappl.1992.72.2.721.
The pontine respiratory group (PRG) facilitates the mechanism for terminating the inspiratory phase but may influence other phases in the respiratory cycle as well. We determined the effects of PRG lesions on the response of the respiratory cycle to superior laryngeal nerve stimulation delivered in each phase of the cycle in decerebrate, vagotomized, paralyzed, and ventilated cats (n = 6). We measured the duration of inspiration (TI) and expiration (TE) for three breaths before and in the perturbed breath and TI for three breaths after the perturbation. The delay to next inspiration was plotted against the phase at which the stimulus was delivered. Before lesioning, premature inspiratory termination was followed by phase-dependent shortening of TE. After lesioning, premature inspiratory termination did not systematically change the following TE. Breath-by-breath variability (measured 50 breaths) increased and stimulus after-effects (prolonged TI in the subsequent cycle) were augmented following lesions. These data indicate that the PRG plays an important role in the control of TE after perturbation and in the stability of the respiratory central pattern generator.
脑桥呼吸组（PRG）促进吸气相终止机制，但也可能影响呼吸周期的其他阶段。我们确定了PRG损伤对去大脑、迷走神经切断、麻痹并通气的猫（n = 6）呼吸周期各阶段中喉上神经刺激的反应的影响。我们测量了干扰呼吸之前的三次呼吸以及干扰呼吸时的吸气时间（TI）和呼气时间（TE），以及干扰后三次呼吸的TI。将下次吸气延迟时间与刺激施加的阶段作图。在损伤前，过早的吸气终止后会出现与阶段相关的TE缩短。损伤后，过早的吸气终止并未系统地改变随后的TE。损伤后逐次呼吸变异性（测量50次呼吸）增加，刺激后效应（后续周期中TI延长）增强。这些数据表明，PRG在干扰后对TE的控制以及呼吸中枢模式发生器的稳定性中起重要作用。
