Ulfberg Jan, Bjorvatn Björn, Leissner Lena, Gyring Jens, Karlsborg Merete, Regeur Lisbeth, Skeidsvoll Håvard, Polo Olli, Partinen Markku
Sleep Disorders Center, Avesta Hospital, SE-774-82 Avesta, Sweden.
Sleep Med. 2007 Nov;8(7-8):768-72. doi: 10.1016/j.sleep.2006.11.015. Epub 2007 Sep 6.
Restless legs syndrome (RLS) is a neurological movement disorder, which often causes sleep problems. However, the comorbidity of this disorder is not well known. This study aimed to document the prevalence of RLS in the general population of Sweden and to identify factors associated with this condition.
A cross-sectional study was performed in Sweden. One thousand subjects aged 18-90 years old underwent telephone interviews. The questionnaire assessed such factors as sleep variables, depressive mood, treatment of diabetes mellitus, and treatment with drugs for depression during the previous four-week period. RLS was diagnosed based on the minimal criteria provided by the International RLS Study Group.
The prevalence of RLS was 5% (5.7% in women, 3.5% in men). Severe or very severe RLS symptoms during the previous week were noted by 64% of the RLS subjects. Factors associated with RLS were insomnia, excessive daytime sleepiness, periodic limb movements in sleep, and depressed mood. Those affected by RLS were not more often consumers of drugs for depression than non-RLS subjects.
RLS is prevalent in the general population in Sweden. RLS negatively influenced sleep and was associated with depressed mood. Antidepressive drug treatment was not associated with RLS.
不宁腿综合征（RLS）是一种神经运动障碍，常导致睡眠问题。然而，这种疾病的合并症尚不清楚。本研究旨在记录瑞典普通人群中RLS的患病率，并确定与该疾病相关的因素。
在瑞典进行了一项横断面研究。对1000名年龄在18至90岁之间的受试者进行了电话访谈。问卷评估了睡眠变量、抑郁情绪、糖尿病治疗以及前四周内使用抗抑郁药物治疗等因素。RLS根据国际RLS研究小组提供的最低标准进行诊断。
RLS的患病率为5%（女性为5.7%，男性为3.5%）。64%的RLS受试者在前一周出现了严重或非常严重的RLS症状。与RLS相关的因素包括失眠、日间过度嗜睡、睡眠期周期性肢体运动和抑郁情绪。RLS患者使用抗抑郁药物的频率并不比非RLS受试者更高。
RLS在瑞典普通人群中普遍存在。RLS对睡眠有负面影响，并与抑郁情绪相关。抗抑郁药物治疗与RLS无关。
