Hollister Clair, Li Vincent W
Department of Dermatology, University of California San Diego, La Jolla, CA 92037, USA.
Nurs Clin North Am. 2007 Sep;42(3):457-65, vii. doi: 10.1016/j.cnur.2007.05.002.
For most of the last century, chronic wound care was a practice of passive techniques, designed to prevent the progression of the wound. In the last decade, however, advanced techniques have focused on improving the wound at the molecular level to accelerate wound healing. Successful modalities include tissue-engineered products, hyperbaric oxygen, negative pressure therapy, electrical stimulation, and recombinant growth factors. This shift in the treatment of wound care saw the development of a recombinant human platelet-derived growth factor, becaplermin, which stimulates granulation and increases the incidence of complete wound closure. Another product is oxidized regenerated cellulose/collagen, which protects growth factors and granulation tissue by inhibiting wound proteases. Used together, an optimal environment for wound healing can be created.
在上个世纪的大部分时间里，慢性伤口护理是一种采用被动技术的做法，旨在防止伤口恶化。然而，在过去十年中，先进技术已聚焦于在分子水平上改善伤口，以加速伤口愈合。成功的治疗方式包括组织工程产品、高压氧治疗、负压疗法、电刺激以及重组生长因子。伤口护理治疗的这一转变见证了重组人血小板衍生生长因子贝卡普勒明的研发，它可刺激肉芽组织生长并提高完全伤口闭合的发生率。另一种产品是氧化再生纤维素/胶原蛋白，它通过抑制伤口蛋白酶来保护生长因子和肉芽组织。将它们一起使用，可以营造出促进伤口愈合的最佳环境。
