小鼠泛酸激酶2的定位与调控
Localization and regulation of mouse pantothenate kinase 2.
作者信息
Leonardi Roberta, Zhang Yong-Mei, Lykidis Athanasios, Rock Charles O, Jackowski Suzanne
机构信息
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.
出版信息
FEBS Lett. 2007 Oct 2;581(24):4639-44. doi: 10.1016/j.febslet.2007.08.056. Epub 2007 Sep 7.
Abstract
Coenzyme A (CoA) biosynthesis is initiated by pantothenate kinase (PanK) and CoA levels are controlled through differential expression and feedback regulation of PanK isoforms. PanK2 is a mitochondrial protein in humans, but comparative genomics revealed that acquisition of a mitochondrial targeting signal was limited to primates. Human and mouse PanK2 possessed similar biochemical properties, with inhibition by acetyl-CoA and activation by palmitoylcarnitine. Mouse PanK2 localized in the cytosol, and the expression of PanK2 was higher in human brain compared to mouse brain. Differences in expression and subcellular localization should be considered in developing a mouse model for human PanK2 deficiency.
摘要
辅酶A（CoA）的生物合成由泛酸激酶（PanK）启动，CoA水平通过PanK亚型的差异表达和反馈调节来控制。PanK2是人类的一种线粒体蛋白，但比较基因组学研究表明，线粒体靶向信号的获得仅限于灵长类动物。人类和小鼠的PanK2具有相似的生化特性，可被乙酰辅酶A抑制，被棕榈酰肉碱激活。小鼠的PanK2定位于细胞质中，与小鼠脑相比，PanK2在人类脑中的表达更高。在开发人类PanK2缺乏症的小鼠模型时，应考虑表达和亚细胞定位的差异。
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