Burgess John A, Walters E Haydn, Byrnes Graham B, Matheson Melanie C, Jenkins Mark A, Wharton Cathryn L, Johns David P, Abramson Michael J, Hopper John L, Dharmage Shyamali C
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia.
J Allergy Clin Immunol. 2007 Oct;120(4):863-9. doi: 10.1016/j.jaci.2007.07.020. Epub 2007 Sep 7.
The association between allergic rhinitis and asthma is well documented, but the temporal sequence of this association has not been closely examined.
We sought to assess the associations between childhood allergic rhinitis and (1) asthma incidence from preadolescence to middle age and (2) asthma persistence to middle age.
Data were gathered from the 1968, 1974, and 2004 surveys of the Tasmanian Asthma Study. Cox regression was used to examine the association between childhood allergic rhinitis and asthma incidence in preadolescence, adolescence, and adult life. Binomial regression was used to examine the association between childhood allergic rhinitis and asthma beginning before the age of 7 years and persisting at age 44 years.
Childhood allergic rhinitis was associated with a significant 2- to 7-fold increased risk of incident asthma in preadolescence, adolescence, or adult life. Childhood allergic rhinitis was associated with a 3-fold increased risk of childhood asthma persisting compared with remitting by middle age.
Childhood allergic rhinitis increased the likelihood of new-onset asthma after childhood and the likelihood of having persisting asthma from childhood into middle age.
Asthma burden in later life might be reduced by more aggressive treatment of allergic rhinitis in early life.
变应性鼻炎与哮喘之间的关联已有充分记录，但这种关联的时间顺序尚未得到仔细研究。
我们试图评估儿童变应性鼻炎与以下两方面的关联：（1）从青春期前到中年的哮喘发病率；（2）持续到中年的哮喘。
数据来自塔斯马尼亚哮喘研究1968年、1974年和2004年的调查。采用Cox回归分析儿童变应性鼻炎与青春期前、青春期及成年期哮喘发病率之间的关联。采用二项回归分析儿童变应性鼻炎与7岁前发病并持续至44岁的哮喘之间的关联。
儿童变应性鼻炎与青春期前、青春期或成年期哮喘发病风险显著增加2至7倍相关。与中年时缓解的儿童哮喘相比，儿童变应性鼻炎与儿童哮喘持续的风险增加3倍相关。
儿童变应性鼻炎增加了儿童期后新发哮喘的可能性以及儿童期至中年期持续性哮喘的可能性。
通过在生命早期更积极地治疗变应性鼻炎，可能会减轻晚年的哮喘负担。
