Breccia Massimo, Martelli Maurizio, Cannella Laura, Russo Eleonora, Finolezzi Erica, Stefanizzi Caterina, Levi Anna, Frustaci Annamaria, Alimena Giuliana
Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy.
Leuk Res. 2008 Feb;32(2):353-5. doi: 10.1016/j.leukres.2007.07.023. Epub 2007 Sep 7.
Philadelphia positive (Ph+) chronic myeloid leukaemia (CML) presenting synchronously or following non-Hodgkin lymphoma (NHL) has only rarely been reported. Herein, we refer on a case of Ph+ CML occurring after a breast cancer and a NHL with multiple relapses. After obtaining complete cytogenetic remission with imatinib, the patient presented a new NHL relapse, that was treated with rituximab concomitantly to imatinib. Therapy was well tolerated and the patient is presently alive in complete remission of either NHL and CML. We also reviewed the literature relating the uncommon association of these two unrelated diseases.
费城染色体阳性（Ph+）慢性髓系白血病（CML）与非霍奇金淋巴瘤（NHL）同步出现或在其之后发生的情况鲜有报道。在此，我们报告一例乳腺癌和多次复发的NHL之后发生Ph+ CML的病例。在使用伊马替尼获得完全细胞遗传学缓解后，患者出现新的NHL复发，在使用伊马替尼的同时用利妥昔单抗进行治疗。治疗耐受性良好，患者目前存活，NHL和CML均处于完全缓解状态。我们还回顾了有关这两种不相关疾病罕见关联的文献。
