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模拟表位疫苗：表位模拟物可诱导抗癌抗体。

Mimotope vaccines: epitope mimics induce anti-cancer antibodies.

作者信息

Riemer Angelika B, Jensen-Jarolim Erika

机构信息

Department of Dermatology, Medical University Vienna, Austria.

出版信息

Immunol Lett. 2007 Oct 31;113(1):1-5. doi: 10.1016/j.imlet.2007.07.008. Epub 2007 Aug 22.

DOI:10.1016/j.imlet.2007.07.008
PMID:17825923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2999752/
Abstract

Mimotopes are epitope-mimicking structures. When applied for immunizations they induce desired antibody specificities exclusively based on the principle of molecular mimicry. This is important as antibodies directed against tumor-associated antigens may harbor diverse biological effects depending on their epitope specificity. Thus they may inhibit or promote tumor growth. This review gives an update on different vaccination strategies based on the mimotope concept.

摘要

模拟表位是模拟抗原决定簇的结构。当用于免疫接种时，它们仅基于分子模拟原理诱导所需的抗体特异性。这一点很重要，因为针对肿瘤相关抗原的抗体根据其抗原决定簇特异性可能具有多种生物学效应。因此，它们可能抑制或促进肿瘤生长。本综述提供了基于模拟表位概念的不同疫苗接种策略的最新信息。

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本文引用的文献

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2
Preclinical studies of carbohydrate mimetic peptide vaccines for breast cancer and melanoma.用于乳腺癌和黑色素瘤的碳水化合物模拟肽疫苗的临床前研究。
Vaccine. 2007 Apr 20;25(16):3022-31. doi: 10.1016/j.vaccine.2007.01.072. Epub 2007 Jan 26.
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Characterization of GD2 peptide mimotope DNA vaccines effective against spontaneous neuroblastoma metastases.对有效对抗自发性神经母细胞瘤转移的GD2肽模拟表位DNA疫苗的特性分析
基于噬菌体的疫苗：一种强大的抗原递送方法。
Vaccines (Basel). 2020 Sep 4;8(3):504. doi: 10.3390/vaccines8030504.
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A nanobody-derived mimotope against VEGF inhibits cancer angiogenesis.一种针对 VEGF 的纳米抗体衍生模拟肽抑制肿瘤血管生成。
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Phage Display-Based Nanotechnology Applications in Cancer Immunotherapy.基于噬菌体展示的纳米技术在癌症免疫治疗中的应用。
Molecules. 2020 Feb 14;25(4):843. doi: 10.3390/molecules25040843.
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Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform.基于新型腺相关病毒模拟表位文库平台推导的HER-2模拟表位抗癌疫苗的概念验证研究。
Oncoimmunology. 2016 Apr 21;5(7):e1171446. doi: 10.1080/2162402X.2016.1171446. eCollection 2016 Jul.
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