模拟表位疫苗：表位模拟物可诱导抗癌抗体。
Mimotope vaccines: epitope mimics induce anti-cancer antibodies.
作者信息
Riemer Angelika B, Jensen-Jarolim Erika
机构信息
Department of Dermatology, Medical University Vienna, Austria.
出版信息
Immunol Lett. 2007 Oct 31;113(1):1-5. doi: 10.1016/j.imlet.2007.07.008. Epub 2007 Aug 22.
Abstract
Mimotopes are epitope-mimicking structures. When applied for immunizations they induce desired antibody specificities exclusively based on the principle of molecular mimicry. This is important as antibodies directed against tumor-associated antigens may harbor diverse biological effects depending on their epitope specificity. Thus they may inhibit or promote tumor growth. This review gives an update on different vaccination strategies based on the mimotope concept.
摘要
模拟表位是模拟抗原决定簇的结构。当用于免疫接种时，它们仅基于分子模拟原理诱导所需的抗体特异性。这一点很重要，因为针对肿瘤相关抗原的抗体根据其抗原决定簇特异性可能具有多种生物学效应。因此，它们可能抑制或促进肿瘤生长。本综述提供了基于模拟表位概念的不同疫苗接种策略的最新信息。
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