Ludolph A C, He F, Spencer P S, Hammerstad J, Sabri M
Center for Research on Occupational and Environmental Toxicology, Portland, Oregon 97201.
Can J Neurol Sci. 1991 Nov;18(4):492-8. doi: 10.1017/s0317167100032212.
3-Nitropropionic acid (3-NPA)--a suicide inhibitor of succinate dehydrogenase--is a widely distributed plant and fungal neurotoxin known to induce a damage to basal ganglia, hippocampus, spinal tracts and peripheral nerves in animals. Recent reports from Northern China indicate that 3-NPA is also likely to be responsible for the development of putaminal necrosis with delayed dystonia in children after ingestion of mildewed sugar cane. This article discusses the role of 3-NPA in the causation of the disease in China, its neurotoxic effects in animals and the potential role for this compound as a probe of selective neuronal vulnerability.
3-硝基丙酸（3-NPA）——琥珀酸脱氢酶的自杀性抑制剂——是一种广泛分布的植物和真菌神经毒素，已知可导致动物基底神经节、海马体、脊髓束和周围神经受损。来自中国北方的最新报告表明，儿童摄入霉变甘蔗后发生的壳核坏死伴迟发性肌张力障碍也可能与3-NPA有关。本文讨论了3-NPA在中国该疾病病因中的作用、其对动物的神经毒性作用以及该化合物作为选择性神经元易损性探针的潜在作用。
