Cardoso João C R, Vieira Florbela A, Gomes Ana S, Power Deborah M
Centre of Marine Sciences (CCMAR), Universidade do Algarve, Campus de Gambelas, Faro 8005-139, Portugal.
Peptides. 2007 Sep;28(9):1902-19. doi: 10.1016/j.peptides.2007.05.016. Epub 2007 Jul 31.
The evolution, function and interaction of ligand-receptor pairs are of major pharmaceutical interest. Comparative sequence analysis approaches using data from phylogenetically distant organisms can provide insights into their origin and possible physiological roles. The present review focuses on the pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP) and their receptors in the metazoa. A PACAP-like peptide is present in tunicates and chordates while VIP- and PACAP/VIP-specific receptors have only been isolated in the latter phyla. The apparently disparate evolution of the ligands and their specific receptors raises questions about their evolution during the metazoan radiation and also about how the ligands may have acquired new functions.
配体-受体对的进化、功能及相互作用是药学领域的主要研究兴趣点。利用系统发育关系较远的生物的数据进行比较序列分析的方法，能够为它们的起源及可能的生理作用提供见解。本综述聚焦于后生动物中的垂体腺苷酸环化酶激活多肽（PACAP）、血管活性肠肽（VIP）及其受体。被囊动物和脊索动物中存在一种PACAP样肽，而VIP及PACAP/VIP特异性受体仅在后者所属的门类中被分离出来。配体及其特异性受体明显不同的进化过程，引发了关于它们在后生动物辐射期间的进化以及配体如何获得新功能的问题。
