Lundin B Samuel, Enarsson Karin, Kindlund Bert, Lundgren Anna, Johnsson Erik, Quiding-Järbrink Marianne, Svennerholm Ann-Mari
Department of Microbiology and Immunology, Institute of Biomedicine, Göteborg University Vaccine Research Institute, Göteborg University, Göteborg, Sweden.
Clin Immunol. 2007 Nov;125(2):205-13. doi: 10.1016/j.clim.2007.07.011. Epub 2007 Sep 10.
Helicobacter pylori causes a life-long infection that may lead to development of gastric adenocarcinoma (GC) and thereby cause major worldwide health problems. The present study was designed to study whether those that develop GC have an altered immune response to H. pylori compared to individuals that remain asymptomatic. When stimulated with H. pylori antigens, T cells from both peripheral blood and gastric mucosa of H. pylori-infected GC patients produced high amounts of IL-10, while the IL-10 production from blood T cells of H. pylori-infected asymptomatic subjects was low. Furthermore, mRNA levels of IL-10 were increased in the gastric mucosa of GC patients. In addition, the frequency of activated CD8(+) T cells was markedly reduced in stomach mucosa of patients with GC compared to asymptomatic individuals. We propose that the increased production of the suppressive cytokine IL-10 in H. pylori-infected GC patients leads to a diminished cytotoxic anti-tumour T-cell response in the stomach, which may contribute to tumour progression in subjects suffering from GC.
幽门螺杆菌会引发终身感染，可能导致胃腺癌（GC）的发生，从而在全球范围内引发重大的健康问题。本研究旨在探讨与无症状个体相比，患GC的个体对幽门螺杆菌的免疫反应是否发生改变。在用幽门螺杆菌抗原刺激时，幽门螺杆菌感染的GC患者外周血和胃黏膜中的T细胞会产生大量白细胞介素-10（IL-10），而幽门螺杆菌感染的无症状受试者血液T细胞产生的IL-10量较低。此外，GC患者胃黏膜中IL-10的mRNA水平升高。此外，与无症状个体相比，GC患者胃黏膜中活化的CD8(+) T细胞频率显著降低。我们认为，幽门螺杆菌感染的GC患者中抑制性细胞因子IL-10的产生增加，导致胃中细胞毒性抗肿瘤T细胞反应减弱，这可能有助于GC患者的肿瘤进展。
