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既往有心肌梗死且射血分数≤35%的患者在植入式心脏复律除颤器使用方面的种族差异。

Racial disparity in the utilization of implantable-cardioverter defibrillators among patients with prior myocardial infarction and an ejection fraction of <or=35%.

作者信息

Thomas Kevin L, Al-Khatib Sana M, Kelsey Richard C, Bush Heather, Brosius Lynne, Velazquez Eric J, Peterson Eric D, Gilliam F Roosevelt

机构信息

Duke University Medical Center, Durham, North Carolina, USA.

出版信息

Am J Cardiol. 2007 Sep 15;100(6):924-9. doi: 10.1016/j.amjcard.2007.04.024. Epub 2007 Jun 27.

Abstract

Age-adjusted sudden cardiac death rates are highest for black patients compared with other racial groups. The prophylactic implantation of an implantable cardioverter-defibrillator (ICD) provides a significant reduction in sudden cardiac death and overall mortality in patients after myocardial infarctions with significant left ventricular systolic dysfunction. The purpose of this study was to determine whether black patients with left ventricular systolic dysfunction were less likely than white patients to receive ICDs for the primary prevention of sudden cardiac death. Data from the National Registry to Advance Heart Health (ADVANCENT) were analyzed to determine which patients with histories of myocardial infarctions and ejection fractions<or=35% received ICDs for the primary prevention of sudden cardiac death. Multivariate logistic regression was used to evaluate the association of patients' race with ICD implantation. Overall, 7,830 patients were identified as eligible candidates for ICDs. Black patients (n=660) were younger, more often women, had less education, had more co-morbidities, and had a lower mean ejection fraction compared with white patients (n=7,170). More than 90% of the study population were insured, and approximately 88% of participants in the registry were enrolled by cardiologists. Blacks were significantly less likely than whites to receive ICDs (30% vs 41%, p<0.001). This difference in ICD use persisted after adjusting for demographics, clinical characteristics, and socioeconomic factors (odds ratio 0.62, 95% confidence interval 0.50 to 0.75, p<0.001). In conclusion, among patients at an increased risk for sudden cardiac death, blacks were significantly less likely to receive ICDs than whites.

摘要

与其他种族群体相比,黑人患者的年龄调整后心源性猝死率最高。对于心肌梗死后出现显著左心室收缩功能障碍的患者,预防性植入植入式心脏复律除颤器(ICD)可显著降低心源性猝死率和总体死亡率。本研究的目的是确定左心室收缩功能障碍的黑人患者与白人患者相比,接受ICD进行心源性猝死一级预防的可能性是否更低。分析了来自国家心脏健康促进注册中心(ADVANCENT)的数据,以确定哪些有心肌梗死病史且射血分数≤35%的患者接受了ICD进行心源性猝死的一级预防。采用多因素逻辑回归来评估患者种族与ICD植入之间的关联。总体而言,7830名患者被确定为ICD的合格候选人。与白人患者(n = 7170)相比,黑人患者(n = 660)更年轻,女性比例更高,受教育程度更低,合并症更多,平均射血分数更低。研究人群中超过90%有保险,注册中心约88%的参与者由心脏病专家登记入组。黑人接受ICD的可能性显著低于白人(30%对41%,p<0.001)。在调整人口统计学、临床特征和社会经济因素后,ICD使用的这种差异仍然存在(优势比0.62,95%置信区间0.50至0.75,p<0.001)。总之,在有心源性猝死风险增加的患者中,黑人接受ICD的可能性显著低于白人。

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