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前庭神经鞘瘤放射外科治疗后脑放射性坏死。

Radiation necrosis of the brain after radiosurgery for vestibular schwannoma.

作者信息

Djalilian Hamid R, Benson Aaron G, Ziai Kasra, Safai Yalda, Thakkar Kunal H, Mafee Mahmood F

机构信息

Department of Otolaryngology, University of California, Irvine Medical Center, Orange, CA 92868, USA.

出版信息

Am J Otolaryngol. 2007 Sep-Oct;28(5):338-41. doi: 10.1016/j.amjoto.2006.09.008.

Abstract

OBJECTIVE

The objective of this study was to obtain a better understanding of radiation-induced brain necrosis after stereotactic radiation therapy for vestibular schwannomas.

STUDY DESIGN

We conducted a retrospective case analysis.

SETTING

The study took place at a tertiary referral center.

PATIENTS

We report on the case of a patient treated with stereotactic radiation who developed radiation-induced necrosis of the ipsilateral temporal lobe.

INTERVENTION

The various interventions in patients with radiation-induced necrosis include steroid treatment, decompression, and hyperbaric oxygen therapy; these are discussed briefly in this article. Owing to the limited symptoms in our patient, she was observed.

MAIN OUTCOME MEASURE

The outcome measure that we evaluated was radiation-induced necrosis of the brain after stereotactic radiation therapy for a vestibular schwannoma.

RESULTS

Patients who undergo stereotactic radiation therapy for vestibular schwannomas are at risk for radiation-induced brain necrosis.

CONCLUSION

We support the development of a national database that would track the long-term complications of stereotactic radiation therapy to help patients make a more informed decision for the treatment of their vestibular schwannomas.

摘要

目的

本研究的目的是更好地了解立体定向放射治疗前庭神经鞘瘤后辐射诱发的脑坏死情况。

研究设计

我们进行了一项回顾性病例分析。

研究地点

该研究在一家三级转诊中心开展。

患者

我们报告了一例接受立体定向放射治疗后出现同侧颞叶辐射诱发坏死的患者病例。

干预措施

辐射诱发坏死患者的各种干预措施包括类固醇治疗、减压和高压氧治疗;本文对此进行了简要讨论。由于我们的患者症状有限,对其进行了观察。

主要观察指标

我们评估的观察指标是立体定向放射治疗前庭神经鞘瘤后辐射诱发的脑坏死情况。

结果

接受立体定向放射治疗前庭神经鞘瘤的患者有发生辐射诱发脑坏死的风险。

结论

我们支持建立一个全国性数据库,跟踪立体定向放射治疗的长期并发症,以帮助患者在治疗前庭神经鞘瘤时做出更明智的决策。

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