痣样基底细胞癌综合征患者髓母细胞瘤放疗后发生的鼻窦癌
Sinonasal carcinoma after irradiation for medulloblastoma in nevoid basal cell carcinoma syndrome.
作者信息
Wallin Jordan L, Tanna Neil, Misra Sasmita, Puri Puja K, Sadeghi Nader
机构信息
The George Washington University School of Medicine, Washington DC, USA.
出版信息
Am J Otolaryngol. 2007 Sep-Oct;28(5):360-2. doi: 10.1016/j.amjoto.2006.10.006.
BACKGROUND
Nevoid basal cell carcinoma syndrome (NBCCS) is associated with multiple basal cell carcinomas, odontogenic cysts, craniofacial anomalies, and childhood medulloblastomas. In addition, it has been associated with irradiation-induced neoplasms including, meningiomas, sarcomas, and gliomas.
METHODS
We present a 19-year-old man with NBCCS who presented with a sinonasal carcinoma 17 years after receiving craniospinal irradiation for treatment of medulloblastoma.
RESULTS
To our knowledge, this is the first report of a sinonasal tumor after irradiation in a patient with NBCCS.
CONCLUSIONS
With this case, the authors examine the genotype of NBCCS patients and their propensity for radiation-induced tumors. In addition, the management of neoplasms in these tumor-sensitive patients is reviewed.
背景
痣样基底细胞癌综合征（NBCCS）与多发性基底细胞癌、牙源性囊肿、颅面畸形及儿童髓母细胞瘤相关。此外，它还与辐射诱发的肿瘤有关，包括脑膜瘤、肉瘤和胶质瘤。
方法
我们报告一名19岁患有NBCCS的男性，其在接受颅脊髓照射治疗髓母细胞瘤17年后出现鼻窦癌。
结果
据我们所知，这是首例关于NBCCS患者放疗后发生鼻窦肿瘤的报告。
结论
通过该病例，作者研究了NBCCS患者的基因型及其发生辐射诱发肿瘤的倾向。此外，还对这些肿瘤敏感患者的肿瘤管理进行了综述。
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