Lippi Giuseppe, Tessitore Nicola, Salvagno Gian Luca, Bedogna Valeria, Bassi Antonella, Montagnana Martina, Lupo Antonio, Guidi Gian Cesare
Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Ospedale Policlinico G.B. Rossi, Piazzale Scuro, 10, 37121-Verona, Italy.
Clin Biochem. 2007 Nov;40(16-17):1336-8. doi: 10.1016/j.clinbiochem.2007.07.007. Epub 2007 Aug 10.
There is debate on the influence of haemodialysis (HD) on lipoprotein(a).
Lp(a), apo A, apo B and high-sensitivity C-reactive protein (hs-CRP) were measured in 46 patients pre- and post-HD.
The median Lp(a) concentration significantly decreased post-HD (106 vs. 145 mg/L, p<0.001). No significant variations were observed for apo A, apo B and hs-CRP. Comparable results were observed with high- and low-flux membranes.
HD is effective in lowering Lp(a).
关于血液透析（HD）对脂蛋白（a）的影响存在争议。
对46例患者在血液透析前后测定脂蛋白（a）、载脂蛋白A、载脂蛋白B和高敏C反应蛋白（hs-CRP）。
血液透析后脂蛋白（a）浓度中位数显著降低（106对145mg/L，p<0.001）。载脂蛋白A、载脂蛋白B和hs-CRP未观察到显著变化。高通量和低通量膜的结果相似。
血液透析对降低脂蛋白（a）有效。
