Muñoz M J, Bea J A, Rodríguez J F, Ochoa I, Grasa J, Pérez del Palomar A, Zaragoza P, Osta R, Doblaré M
Lagenbio-Ingen, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Spain.
J Biomech. 2008;41(1):93-9. doi: 10.1016/j.jbiomech.2007.07.013. Epub 2007 Sep 10.
Samples of male and female mice skin were tested under monotonic and cyclic loading to mechanically characterize the tissue for large deformations. Cyclic tests have shown a typical Mullins effect widely known for elastomers and other soft tissues. No statistical difference was found in the maximum stretch of the sample after the fifth loading cycle for male (1.26 +/- 0.035) and female (1.18 +/- 0.083). However, larger dispersion was obtained for the maximum stress for both genders, 0.61 +/- 0.16 MPa for male and 0.78 +/- 0.32 MPa for female. Results show the presence of inelastic strain and stress softening in the skin at large deformations. They also have shown how stress softening and residual strain change with the magnitude of the applied load. Good correlation was observed between the residual strain and the maximum strain previously attained by the sample during loading for all samples. However, the correlation was different between genders.
对雄性和雌性小鼠的皮肤样本进行了单调加载和循环加载测试，以从力学角度表征该组织在大变形情况下的特性。循环测试显示出一种典型的穆林斯效应，这在弹性体和其他软组织中广为人知。在第五次加载循环后，雄性样本（1.26±0.035）和雌性样本（1.18±0.083）的最大拉伸量未发现统计学差异。然而，两性的最大应力离散度更大，雄性为0.61±0.16兆帕，雌性为0.78±0.32兆帕。结果表明，在大变形情况下，皮肤中存在非弹性应变和应力软化现象。研究还展示了应力软化和残余应变如何随外加负荷大小而变化。对于所有样本，在残余应变与样本在加载过程中先前达到的最大应变之间观察到良好的相关性。然而，两性之间的相关性有所不同。
