Baird G J, Fontaine M C
Scottish Agricultural College Veterinary Services, 5 Bertha Park View, Perth PH1 3FZ.
Moredun Research Institute, International Research Centre, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, Scotland, UK.
J Comp Pathol. 2007 Nov;137(4):179-210. doi: 10.1016/j.jcpa.2007.07.002. Epub 2007 Sep 10.
Caseous lymphadenitis (CLA) of sheep, caused by Corynebacterium pseudotuberculosis, has been a significant disease in the majority of sheep-rearing regions for over a century. Because of the chronic and often sub-clinical nature of the infection, it has proved difficult to control and prevalence is high in many parts of the world, which in turn leads to significant economic losses for farmers. This review describes the important characteristics of C. pseudotuberculosis and examines the pathogenesis and epidemiology of the infection in sheep. The review also discusses the immune response to infection and describes the methods that have been developed to control CLA, with particular emphasis on the use of vaccination and serological testing.
绵羊干酪性淋巴结炎（CLA）由伪结核棒状杆菌引起，在大多数养羊地区，这种疾病已存在一个多世纪，一直是一种重要病害。由于感染具有慢性且往往为亚临床的特性，事实证明难以控制，在世界许多地区发病率都很高，进而给养殖户造成重大经济损失。本综述描述了伪结核棒状杆菌的重要特征，并研究了绵羊感染的发病机制和流行病学。该综述还讨论了对感染的免疫反应，并介绍了为控制CLA而研发的方法，特别强调了疫苗接种和血清学检测的应用。
